Abstract

Objectives: Evaluate effect of high-dose nebulize corticoid and parenteral corticoid in the treatment of asthma attack in children. 

Subjects and methods: The study was conducted on 150 pediatric patients with acute asthma attack who were hospitalized for treatment at Pediatrics Center of Hue’s Central Hospital during the period from April 2017 to April 2018. The patients with moderate acute asthma attack were divided in 2 random groups with similarities in age: Group I-TB (60 pediatric patients) with treatment of nebulized salbutamol in combination with high-dose nebulized Budesonide, Group II –TB (60 pediatric patients) with treatment of nebulized salbutamol in combination with oral prednisolone. The patients with severe acute asthma attack were also divided in 2 random groups with similarities in age: Group I-N (15 pediatric patients) with treatment of nebulized salbutamol and intravenous Methylprednisolone in combination with highdose nebulized Budesonide, Group II-N (15 pediatric patients) with treatment of nebulized salbutamol and intravenous Methylprednisolone. Evaluate effect of each group after 1 hour (T1), after 6 hours (T6), after 12 hours (T12) and after 24 hours (T24).
Results: The group with treatment of nebulized Budesonide had better therapeutic efficacy than group with oral prednisolone at T1 (p<0.01) and T3 (p<0.05). The group with nebulized salbutamol in combination with intravenous Methylprednisolone had better therapeutic efficacy than group with only intravenous Methylprednisolone at T1 (p<0.01) and T3 (p<0.05). The therapeutic efficacy was similar between groups at T6, T12, and T24 (p>0.05). The average duration of hospitalization in group with nebulized salbutamol
(4.25 days) was shorter than group with oral prednisolone (5.03 days) (p<0,05). The average duration of hospitalization in group with nebulized salbutamol in combination with intravenous Methylprednisolone (4.93 days) was shorter than group with only intravenous Methylprednisolone (7 days) (p<0.05).
Conclusion: The use of high-dose of nebulized cortcoid in instead of oral corticoide (in treatment of moderate acute asthma attack) or in combination with intravenous corticoide (in treatment of severe acute asthma attack) were helpful in early improving symptoms of asthma thus help shorter the duration of hospitalization.