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Abstract
Bachground: Ultrasound-guided large core needle biopsy technique has widely been applied in the diagnosis of adult abdominopelvic, mediastinal cavity, breast and neck tumors. There are few reports on ultrasound-guided biopsy using large-core needle in pediatric solid tumor. This study was to evaluate the ultrasound features and the diagnostic value of ultrasound-guided core needle biopsy for pediatric retroperitoneal tumors.
Methods: The pediatric patients with retroperitoneal tumor that determined by ultrasound, CT or MRI examination and underwent ultrasound guided core needle biopsy from October 2018 to January 2020 were reviewed at Vietnam National Children’s Hospital. A minimum of five cores in each case was obtained. 13 patients were operated and had surgical pathology results. The ultrasound features and the diagnostic accuracy of ultrasound-guided core needle biopsy were evaluated.
Results: Fifty - two patients (25 males, 27 females) were enrolled into the study. Conventional ultrasound examination showed irregular hypoechoic or mixed echo masses and calcification and liquefied necrosis. The ratio of vascular encased tumors was 61.5%. The quality of tissue sample was enough to make diagnosis was 98.1% (51/52). Only one case was misdiagnosed because of inadequate tissue sample. The diagnostic accuracy of ultrasound guided core needle biopsy compared to subsequent surgical histopathology was 76.9 % (10/13). Retroperitoneal tumor pathology varied with neuroblastic tumor was 86.3% (60.8% NB, 11.8% GNB and 13.7% GN), ACC was 5.9%, germ cell tumor was 4.0% (2.0% teratoma, 2.0% yolk sac tumor) and extra renal malignant rhadoid tumor was 2.0%. No serious complication, hemorrhage or infection occurred.
Conclusions: Ultrasound-guided core needle biopsy seems to be an accurate, minimally invasive, and safe diagnostic method of pediatric retroperitoneal tumor.
References
Brennan, C., et al., Solid malignant retroperitoneal masses-a pictorial review. Insights into Imaging, 2014. 5(1): p. 53-65.
Campagna, G., et al., Evolving biopsy techniques for the diagnosis of neuroblastoma in children. Journal of pediatric surgery, 2018. 53(11): p. 2235-2239.
Gupta, A., et al., Analysis of needle versus open biopsy for the diagnosis of advanced stage pediatric neuroblastoma. Pediatric blood & cancer, 2006. 47(7): p. 875-879.
Sklair-Levy, M., et al., Percutaneous image- guided needle biopsy in children-summary of our experience with 57 children. Pediatric radiology, 2001. 31(10): p. 732-736.
Wang, H., et al., Ultrasound-guided core needle biopsy in diagnosis of abdominal and pelvic neoplasm in pediatric patients. Pediatric surgery international, 2014. 30(1): p. 31-37.
Willman, J.H., K. White, and C.M. Coffin, Pediatric core needle biopsy: strengths and limitations in evaluation of masses. Pediatric and Developmental Pathology, 2001. 4(1): p. 46-52.
Zhao, L., et al., Ultrasound-guided core needle biopsy in the diagnosis of neuroblastic tumors in children: a retrospective study on 83 cases. Pediatric surgery international, 2017. 33(3): p. 347-353.
Hassan, S.F., et al., Needle core vs open biopsy for diagnosis of intermediate-and high-risk neuroblastoma in children. Journal of pediatric surgery, 2012. 47(6): p. 1261-1266.
do Rosário Matos, M., A. Ferreira, and R. Carneiro. Retroperitoneal masses in children- beyond neuroblastoma and Wilms tumor. 2011. European Congress of Radiology 2011.
Georgantzi, K., et al., Diagnostic ultrasound- guided cutting needle biopsies in neuroblastoma: A safe and efficient procedure. Journal of pediatric surgery, 2019. 54(6): p. 1253-1256.
De la Monneraye, Y., et al., Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines. Pediatric blood & cancer, 2019. 66(6): p. e27641.
Deeney, S., et al., Diagnostic utility of core needle biopsy versus open wedge biopsy for pediatric intraabdominal solid tumors: Results of a prospective clinical study. Journal of pediatric surgery, 2017. 52(12): p. 2042-2046.
Garrett, K.M., et al., Percutaneous biopsy of pediatric solid tumors. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2005. 104(3): p. 644-652.
Hugosson, C., et al., Ultrasound-guided biopsy of abdominal and pelvic lesions in children. A comparison between fine-needle aspiration and 1.2 mm-needle core biopsy. Pediatric radiology, 1999. 29(1): p. 31-36.
Hussain, H.K., et al., Imaging-guided core biopsy for the diagnosis of malignant tumors in pediatric patients. American Journal of Roentgenology, 2001. 176(1): p. 43-47.
Mullassery, D., et al., Open versus needle biopsy in diagnosing neuroblastoma. Journal of pediatric surgery, 2014. 49(10): p. 1505-1507.
Sebire, N.J. and D.J. Roebuck, Pathological diagnosis of paediatric tumours from image- guided needle core biopsies: a systematic review. Pediatric radiology, 2006. 36(5): p. 426-431.
| Published | 09-01-2025 | |
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| Issue | No. 66 (2020) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2020.66.13 | |
| Keywords | U sau phúc mạc, sinh thiết kim, giá trị chẩn đoán, u nguồn gốc thần kinh, u nguyên bào thần kinh Retroperitoneal tumor, Core needle biopsy, Diagnostic accuracy, neuroblastic tumor, Neuroblastoma |
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