Abstract
ABSTRACT
Primary Meningeal Melanoma: A Case Report and Literature Review
Background/Objectives: Primary meningeal melanoma is an extremely rare malignant tumor with aggressive biological behavior and poor prognosis. We report a case of rapidly progressive primary meningeal melanoma with liver metastases after gross total resection to contribute additional real-world data on this rare disease.
Case report: A 41-year-old male patient was diagnosed with primary meningeal melanoma in the left occipital region and underwent gross total microsurgical resection. Three months after surgery, the disease progressed with liver metastases. The patient received three cycles of pembrolizumab monotherapy; however, follow-up evaluation demonstrated continued progression of hepatic lesions according to RECIST 1.1 criteria.
Conclusions: This case highlights the aggressive clinical course, early distant metastasis, and limited response to immunotherapy in primary meningeal melanoma. Close postoperative surveillance, multidisciplinary management, and molecular profiling may play important roles in optimizing treatment strategies.
Keywords: primary meningeal melanoma; pembrolizumab; immunotherapy;
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| Published | 18-08-2026 | |
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| Issue | Vol. 18 No. 5 (2026) | |
| Section | Case report | |
| DOI | 10.38103/jcmhch.18.5.16 | |
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