Abstract

Objectives: To evaluate the correlation between the CHA₂DS₂-VASc-HSF score and the extent of coronary artery lesions, SYNTAX score, NT-proBNP levels, and left ventricular ejection fraction (LVEF).

Methods: A cross-sectional study was conducted on 114 patients diagnosed with ACS admitted to the Cardiovascular Center – Hue Central Hospital between May 2023 and August 2024.

Results: The mean age was 67.34 ± 11.69 years, with 58.8% being male. The mean CHA₂DS₂-VASc-HSF score was 4.17 ± 1.33, with 42.1% of patients having a score >4. The score showed a moderate positive correlation with the number of affected coronary vessels (r = 0.443, p < 0.05) and the SYNTAX score (r = 0.418, p < 0.05). There was a statistically significant difference in CHA₂DS₂-VASc-HSF scores across low, intermediate, and high SYNTAX score groups (p < 0.001). A CHA₂DS₂-VASc-HSF score ≥ 4.5 predicted moderate-to-severe coronary artery disease with a sensitivity of 53.8% and specificity of 83.3% (AUC = 0.762). Age, smoking, hypertension, SYNTAX score, and CHA₂DS₂-VASc-HSF score were significant predictors of moderate-to-severe coronary artery disease, with the SYNTAX score being an independent risk factor.

Conclusion: The CHA₂DS₂-VASc-HSF score is significantly associated with the severity of coronary artery lesions in ACS patients. A score ≥ 4.5 is a useful threshold for predicting moderate-to-severe coronary artery disease, with moderate sensitivity and high specificity.