Abstract

Objective: This study aims to assess the effect of the severity of liver cirrhosis (according to Child-Pugh classification) on lipid profile changes in cirrhotic patients treated as inpatients at the Department of Gastroenterology, Thai Binh Provincial General Hospital.

Methods: The study included 102 cirrhotic patients who were hospitalized at the Department of Gastroenterology, Thai Binh Provincial General Hospital. Patients were classified according to the severity of liver cirrhosis based on the Child-Pugh classification (Child A, B, C). Lipid profile parameters (Triglycerides, Cholesterol, HDL-C, LDL-C) were measured, and the relationship between cirrhosis severity and lipid profile changes was analyzed. Additionally, clinical factors such as prothrombin ratio, albumin, and bilirubin were assessed to clarify their relationship with lipid profiles.

Results: Among the 102 patients, 89.2% were male and 10.8% were female. The rate of cirrhotic patients with dyslipidemia was 83.3%. Dyslipidemia was found to increase in patients with severe cirrhosis (Child B and C), with statistical significance (p < 0.05). Lipid profile parameters (Triglycerides, Cholesterol, HDL-C, LDL-C) changed according to the severity of cirrhosis, but the changes were not significant for all lipid parameters. Cholesterol, HDL-C, and LDL-C levels tended to decrease as the prothrombin ratio and albumin levels decreased. Higher serum bilirubin levels were associated with decreased cholesterol and HDL-C levels.

Conclusion: The severity of cirrhosis (according to Child-Pugh classification) affects lipid profile changes, particularly cholesterol, HDL-C, and LDL-C. Clinical factors such as prothrombin ratio, albumin, and bilirubin also correlate with lipid profile changes.