Abstract

Introduction: Negative Pressure Wound Therapy (NPWT) has been widely applied in the local treatment of wounds, promoting wound healing, reducing the risk of infection, and minimizing complications. Recently, Negative Pressure Wound Therapy with Instillation and Dwell (NPWTi-d) using various irrigation solutions has been introduced. This method consists of three phases: instillation, dwell, and suction. In addition to providing similar benefits as traditional NPWT, NPWTi-d shortens the treatment duration for infections, accelerates wound bed preparation, and is particularly effective for infected soft tissue wounds.

Methods: This was a prospective, uncontrolled descriptive study conducted on 32 patients with infected soft tissue wounds treated locally using the NPWTi-d system.

Results: The mean age of patients was 52.3 ± 18.9 years (ranging from 9 to 81 years), with males accounting for 59.4% of cases. The mean wound area before treatment was 15.3 ± 21.8 cm² and decreased to 14.8 ± 23.5 cm² after treatment. The most common causative pathogen was methicillin-resistant Staphylococcus aureus (MRSA), found in 53.1% of cases. On average, each patient required 2.66 ± 0.9 NPWTi-d sessions. The mean time to bacterial clearance was 11.5 ± 6.8 days, and the average hospital stay was 23.6 ± 11.2 days.

Conclusion: NPWTi-d has demonstrated effectiveness in the treatment of infected soft tissue wounds.