Abstract
Objective: to evaluate the characteristic of the malnutrition, inflammation, atherosclerosis (MIA) syndrome in patients with end-stage renal disease (ESRD) who were in predialysis; relations between MIA syndrome and the outcome.
Subjects and methods: A descriptive, cross-sectional study on 51 patients with end-stage renal disease (ESRD) who were in predialysis. Inflammatory marker (hs CRP) and nutritional parameters (albumin, prealbumin, BMI) were determined. Carotid atherosclerosis was investigated by ultrasonographically evaluated carotid intima-media thickness (CIMT).
Results: The prevalence of malnutrition was 47.1%, inflammation was 80.4% and atherosclerosis was 62.7%. Malnourished patients had higher hs CRP level (9.00±11.47 vs 3.06±4.95 mg/L, p<0.05) compared with well-nourished patients. Inflammated patients had elevated IMT and a higher prevalence of carotid plaque. There was not relation between nutritional markers and atherosclerosis. The outcome was 80% in patients who had more than two risk factors.
Conclusion: There were a relation between malnutrition, inflammation, atherosclerosis and outcome in patients end-stage renal disease (ESRD) who were in predialysis
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