Downloads
Abstract
Neuroblastoma is one of the malignant solid tumours that often seen in children. Early in diagnosis combine with histology classification suitably and genetic analysis play an important role in treatment and prognosis. Objective: Evaluate histology characteristics, prognotic factors and analyse genetic aberrations in a case of poorly differentiated neuroblastoma. Subject: a male patient that has retroperitoneal tumour operated in National Hospital of Paediatrics. Method: A case report. Result: Histology showes a case of neuroblastoma poorly differentiated, high MKI and genetic analysis presented MYCN amplification, 1p del, 11q del, 17q gain. Conclusion: Neuroblastoma is a multiple subtype malignant tumour. Poorly diferentiated neuroblastoma, high MKI, high staging, MYCN amplification are the unfavorable criterias leading to very poor prognosis in treatment.References
Hoàng Ngọc Thạch (2009), Nghiên cứu đặc điểm hình thái học và một số yếu tố tiên lượng u nguyên bào thần kinh ở trẻ em, Luận văn Thạc sĩ Y học, chuyên ngành Giải phẫu bệnh, mã số 60.72.01.
Phùng Tuyết Lan (2007), Nghiên cứu phân loại và nhận xét kết quả điều trị u nguyên bào thần kinh ở trẻ em tại Bệnh viện Nhi Trung ương (2002 - 2006), Luận án Tiến sĩ Y học, chuyên ngành Nhi Khoa, mã số 3.01.43
Berstein M.L., Leclerc J.M., Bunin G. et al (1992), "A Population Base Study of Neuroblastoma Incidence, Survival and Mortality in North America", J Clin Oncol, 10, pp. 323-29.
Brodeur G.M, Maris J.M (2002), Neuroblastoma, Principles and pratice of Paeditrics Oncology, Philip A. Pizzo, David G. Poplack, Williams and Wlkins, pp. 895-937.
Brodeur G.M (2003), Neuroblastoma: Biological Insights into a Clinical Enigma, Nat Rev Cancer, 3, pp, 203-16.
Mathay K.K and Yamashiro D (2000), Neuroblastoma, Cancer medicine, Bast R.C, Kufe D.W, Polloket R.E et al. London, Decker B.C, pp. 2185-97.
Schwab M, Westermann F, Hero B, Berthold F (2003), Neuroblastoma: biology and molecular and chromosomal pathology, Lancer oncol, 4, pp.472-480.
Shimada H, Amros I.M, Dehner L.P et al (1999). Terminology and Morphologic Criteria of Neuroblastic Tumour, Cancer, 86(2), PP. 231-41.
Shimada H, Umehara S, Monobe Y, et al (2001), International neuroblastoma pathology classification for prognotic evaluation of pateints with peripheral neuroblastic tumours. A report from the children's cancer group, Cancer, 92, pp. 2451-2461.
| Published | 06-03-2025 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | No. 28 (2015) | |
| Section | Case report | |
| DOI | ||
| Keywords | u nguyên bào thần kinh, u hạch thần kinh neuroblastoma, ganglioneuroma |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Journal of Clinical Medicine Hue Central Hospital