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Abstract
Objective: To determine the clinical and biologic features. To evaluate the effect of treatment in children with ALL in the Children Hospital 2 Method: Review medical records to describe the clinical and biologic features and to evaluate the effect of Fralle 2000 protocol in 59 children with ALL who were admitted to the Children Hospital 2 from January 2012 to January 2014 Results: Age 1-10, mean age 4.9±3.6 male/female ratio was 1.36/1. All of them had fever, anemia, hepatomegaly at presentation. 98.3% (58/59) patients were achieved a complete remission one out of 59 patients was not achieved complete remission after first reduction... After 2 years follow-up, 25.4%
15/59) were replased and 23.7% (13/59) were died. The overall survival was 76.2% and the disease free survival was 69.5%. Several side effects in reduction including: infection (40.7%), mucositis (52%), hypertransaminase (44%), nausea (30%), hypofirinogen (39%). Days of hospitalization in induction was 55 days (49-65 days). Conclusions: Despite the excellent initial response to the Fralle 2000 protocol, we recommend more available standards to identify risk group, including MRD after reduction because of the high replase rateReferences
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