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Abstract
Background: Neuroblastoma (NB) is the most common pediatric extracranial malignant solid tumor and of neural crest origin. Children hospital #2 adopted the LINES protocol (European Low and Intermediate Risk Neuroblastoma, a SIOPEN study) since 2012 within a limited resourse. Non - high risk neuroblastoma, low - and intermediate - risk categories outcome study takes us more experience in treatment.
Methods: All eligible patients with non - high risk neuroblastoma treated between January 2013 and December 2017 were included in case series study.
Results: The study included 37 patients, 14 male (62,2%) and 23 female (37,8%). Median age is 19,8 month old. Low risk percentage is 67,6%, medium risk accounts for 32,4%. Accumulating percentage at 5 years overall survival is 95% ± 4%. Medium EFS length in both groups is 7,7 years. Accumulating EFS at 5 years is 95 ± 4%. In low - risk group OS rate is 100%. In medium - risk group, median OS length is 6,5 ± 0,5 years, EFS is 5,7 ± 0,7 years. The 5 - year overall and event - free survival (OS and EFS) average in medium - risk group is 83% ± 11%.
Conclusions: A high rate of survival is currently achievable in patients with non - high risk neuroblastoma by surgery or chemotherapy and surgery.
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| Published | 26-12-2024 | |
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| Issue | No. 91 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.91.11 | |
| Keywords | U nguyên bào thần kinh, nguy cơ không cao, phẫu thuật cắt bỏ hoàn toàn và không hoàn toàn Neuroblastoma, non - high risk, surgery, complete resection, incomplete resection |
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