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Abstract
Background: Thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the alpha and beta chains of hemoglobin, resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals.
Objective: This study aimed to estimate frequency and to describe the clinical features, laboratory parameters with thalassemia at Nam Dong and A Luoi districts.
Study design: A cross-sectional descriptive study was performed during a two-year period from 2012 to 2014.
Results and conclusions: The prevalence of thalassemia was 12.4%, including three types of hemoglobinopathies: HbE, β-thalassemia, and HbCs. The prevalence of HbE was 10.4%, HbCs was 0.5%, and heterozygous β-thalassemia was 1.7%. The disease forms included homozygous HbE, heterozygous HbE, HbE/β-thalassemia, heterozygous β-thalassemia, homozygous HbCs, and heterozygous HbCs. The prevalence of hemoglobinopathies in ethnic minority groups was significantly higher than in the Kinh group, with rates of 11.8% vs. 2.8% for HbE. The β^E gene frequency was 0.0532 (0.0608 in minority groups and 0.0014 in the Kinh group), showing a statistically significant difference between the two populations. The α^CS gene frequency was 0.0041, and the β-thalassemia gene frequency was 0.0086.
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| Published | 20-06-2014 | |
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| Issue | No. 20 (2014) | |
| Section | Original article | |
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| Keywords | Thalassemia, tỷ lệ mắc, tần suất Thalassemia, prevalence, frequency |
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