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Abstract
Objective: To evaluate factors related to serum antimüllerian hormone levels changes at 6 months after laparoscopic endometrioma cystectomy.
Methods: From 01/2015 to 10/2016, we performed a prospective longitudinal study at Hanoi Obstetrics and Gynecology Hospital. Women aged 18-40, with ovarian endometriosis, which was confirm in post-operative pathology, and underwent laparoscopic endometrioma cystectomy were recruited to the study. Exclusion criteria included post-menopause, polycystic ovarian syndrome, previous ovarian surgery, combined with other ovarian disorders, hormone disorders, being pregnant during study period and refusal participation. Participant’s characteristics, endometriomas and surgery was collected. The serum AMH level was measured pre-operation, and 6-month post-operation.
Results: 86.5% of participants was under 35 years old. At 6-month postoperation, the mean AMH level decreased significantly compared to at preoperatoin, from 4.47 ng/mL to 1.96 ng/mL (p < 0.001). The magnitude of AMH level decline were 47.8± 35.9%. The AMH levels decreased more in bilateral cyst (77% vs 37,6% in unilateral cyst), cyst diameter > 6cm when cysts are on one ovary (53.5% vs 31.6% in cysts <6cm) and cyst at stage 4 according to rASRM (63.3% vs 34.5% in stage 3). The changes of AMH levels was independent to BMI and CA125 levels.
Conclusions: Bilateral, large and 4-stage according to rASRM ovarian endometrioma cysts was factors related to serum antimüllerian hormone levels decline at 6 months after laparoscopic ovarian endometrioma cystectomy.
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| Published | 20-12-2024 | |
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| Issue | Vol. 16 No. 9 (2024) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.16.9.11 | |
| Keywords | Nội soi bóc nang LNMTC buồng trứng, AMH, yếu tố liên quan, 6 tháng sau mổ Laparoscopic cystectomy of endometriomas, Anti-Mullertian Hormone (AMH), related factors, 6-month postoperation |
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