Abstract
In obese patients, plasma leptin concentration is high. This problem is called "leptin resistance". In reverse, adiponectin concentration is low in overweight and obese patients with insulin resistance, dyslipidemia.
Objectives: 1. To determine the plasma leptin and adiponectin concentration in overweight and obese patients. 2. To evaluate the correlation between plasma leptin concentration with plasma adiponectin, glucose concentration, BMI and blood pressure in overweight and obese patients.
Methods: The study was carried out on 137 people who were divided in two group: 67 normal individuals and 70 overweight and obese patients. Concentrations of leptin and adiponectin was determined by ELISA.
Results: concentrations of leptin in control group is 6.75±5.17 ng/ml, overweight group is 8.95 ± 4.98 ng/ml, and obese group is 11.59±5.76 ng/ml. Concentrations of adiponectin in control group is 9.67 ±5.06 μg/ml, overweight group is 7.81±4.83 μg/ml, and obese group is 5.87±4.1 μg/ml.
Conclusions Leptin concentration is increasing from control group to overweight and obesity patients gradually. Adiponectin concentration is inversely.
References
Trần Khánh Chi, Phạm Thiện Ngọc, Phạm Thị Thu Vân (2011), “Nghiên cứu nồng độ adiponectin huyết thanh ở người rối loạn dung nạp glucose và bệnh nhân đái tháo đường typ 2 mới phát hiện lần đầu”, Tạp chí Nghiên cứu Y học, Trường Đại học Y Hà Nội, 74(3), tr. 75-80.
Trần Hữu Dàng (2011), Bệnh béo phì (chuyên khảo), Nhà xuất bản Đại học Huế.
Nguyễn Kim Lưu (2012), Nghiên cứu sự biến đổi nồng độ adiponectin ở bệnh nhân đái tháo đường týp 2, Luận án Tiến sĩ Y học, Học viện Quân Y.
B. T. Huang, Y. Peng, W. Liu, et al (2015), "Lean mass index, body fat and survival in Chinese patients with coronary artery disease", QJ Med, http://doi:10.1093/qjmed/hcv013.
David M. Maahs, Richard F. Hamman, Ralph D'Agosino Jr, et al (2009), "The Association between Adiponectin/Leptin Ratio and Diabetes Type: The Search for Diabetes in Youth Study", J Pediatr, 155(1), pp. 133-135.
Erkin M Mirrakhimov, Alina S Kerimkulova, Olga S Lunegova, et al (2014), "The association of leptin with dyslipidemia, arteial hypertension and obesity in Kyrgyz (Central Asian nation) population", J Nutr Metab, 7(411), Published online.
H. Mendieta Zerón, Gabriela Herrera Segura, C. F. Layton Tovar, et al (2013), "The Adiponectin/Leptin Ratio is a Useful Tool To Evaluate the metabolic Status in an Obstetrical Intensive Care Unit", Rom. J. Intern Med, 51(2), pp. 107-113.
Hsin-Hua Chou, Lung-An Hsu, Semon Wu, et al (2014). "Leptin-to-Adiponectin ratio is Related to Low Grade Inflammation and Insulin Resistance Independent of Obesity in Non-Diabetic Taiwanese: A Cross-Sectional Cohort Study", Acta Cardiol Sin, 30, pp. 204-214.
Kazuhiko Kotani, Naoki Sakane (2011), "Leptin: Adiponectin Ratio and Metabolic Syndrome in the General Japanese Population", Korean J Lab Med, 31, pp. 162-166.
Mariusz Stepien, Anna Stepien, Rafat N. Wlazet, et al (2014), "Predictors of Insulin Resistance in Patients With Obesity: A Pilot Study", Angiolog, (1), pp. 22-23.
Mehmet Akif Buyukbese, Ali Cetinkaya, Ramazan Kocabas, et al (2004), "Leptin levels in obese women with and without type 2 diabetes mellitus", Mediators of Inflammation, 13(5/6), 321-325.
Zaid AL-Hamodi, Molham AL-Habori, Ali AL-Meeri, et al (2014), "Association of adipokines, leptin/adiponectin Ratio and C-reactive protein-with obesity and type 2 diabetes mellitus", Diabetology & Metabolic Syndrome, 6(99), pp. 34-39.
| Published | 07-09-2015 | |
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| Issue | No. 30 (2015) | |
| Section | Original article | |
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| Keywords | leptin, adiponectin, thừa cân, béo phì leptin, adiponectin, overweight, obese |
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