Đánh giá đáp ứng điều trị ung thư biểu mô tế bào gan sau nút mạch hóa chất (TACE) theo mRECIST

Downloads

Download data is not yet available.
PDF (Tiếng Việt)     134    33

Abstract

Purpose: To evaluate the treatment response of hepatocellular carcinoma (HCC) after transarterial
chemoembolization (TACE) using mRECIST.
Methods: Diagnosis of HCC was based on EASL 2018, and an indication of TACE was based on SIR
practice guideline. Treatment responses were evaluated at < 3 - month, 3 - 6 - month, 6 - 12 - month and
> 12 - month intervals.
Results: Forty - sixpatients (male/female 39/7) with the mean age 61.5 ± 11.2 years were enrolled in the
present study. The mean follow - up duration was 223 days (range, 42 - 723 days). The mean of maximal
HCC diameter was 62mm (range, 10 - 153mm). 23.9% of patients had portal vein thrombosis (PVT). The rates of complete response of the target lesions at the < 3 - month, 3 - 6 - month, 6 - 12 - month and >
12 - month were 33.3%; 33.3%; 35.3% and 33.3%, respectively. Progression disease was seen in 16.7%.
Infiltrative type, diameter > 10cm, bilobar HCC, and portal vein thrombosis were predictors for recurrence.
Conclusion: TACE offered short - term therapeutic control of HCC when using mRECIST

https://doi.org/10.38103/jcmhch.2021.74.6

References

Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn

RS, Abecassis MM, et al. Diagnosis, Staging,

and Management of Hepatocellular Carcinoma:

Practice Guidance by the American

Association for the Study of Liver Diseases.

Hepatology. 2018. 68: 723-750.

Sieghart W, Hucke F, Peck - Radosavljevic M.

Transarterial chemoembolization: modalities,

indication, and patient selection. J Hepatol.

62: 1187-95.

EASL. EASL Clinical Practice Guidelines:

Management of hepatocellular carcinoma. J

Hepatol. 2018. 69: 182-236.

Llovet JM, Real MI, Montaña X, Planas R,

Coll S, Aponte J, et al. Arterial embolisation

or chemoembolisation versus symptomatic

treatment in patients with unresectable

hepatocellular carcinoma: a randomised

controlled trial. Lancet. 2002. 359: 1734-9.

Lencioni R, de Baere T, Soulen MC, Rilling

WS, Geschwind JF. Lipiodol transarterial

chemoembolization for hepatocellular

carcinoma: A systematic review of efficacy and

safety data. Hepatology. 2016. 64: 106-16.

Ichikawa T, Machida N, Sasaki H, Tenmoku A,

Kaneko H, Negishi R, et al. Early Prediction

of the Outcome Using Tumor Markers and

mRECIST in Unresectable Hepatocellular

Carcinoma Patients Who Underwent

Transarterial Chemoembolization. Oncology.

91: 317-330.

Gaba RC, Lokken RP, Hickey RM, Lipnik

AJ, Lewandowski RJ, Salem R, et al. Quality

Improvement Guidelines for Transarterial

Chemoembolization and Embolization of

Hepatic Malignancy. J Vasc Interv Radiol. 2017.

: 1210-1223 e3.

Llovet JM , Lencioni R. mRECIST for HCC:

Performance and novel refinements. J Hepatol.

72: 288-306.

Younes EH, Zahra HF, Soumaya BM, Maria L,

Nada L, Hakima A, et al. Study of predictive factors

of complete response after chemoembolization

for unresectable hepatocellular carcinoma in 162

patients. Clin Exp Hepatol. 2020. 6: 313-320.

Domaratius C, Settmacher U, Malessa C,

Teichgraber U. Transarterial chemoembolization

with drug - eluting beads in patients with

hepatocellular carcinoma: response analysis with

mRECIST. Diagn Interv Radiol. 2021. 27: 85-93. 11. Vesselle G., Quirier-Leleu C., Velasco S.,

Charier F., Silvain C., Boucebci S., et al.

Predictive factors for complete response of

chemoembolization with drug - eluting beads

(DEB-TACE) for hepatocellular carcinoma. Eur

Radiol. 2016. 26: 1640-1648.

Dioguardi Burgio M., Sartoris R., Libotean C.,

Zappa M., Sibert A., Vilgrain V., et al. Lipiodol

retention pattern after TACE for HCC is a predictor

for local progression in lesions with complete

response. Cancer Imaging. 2019. 19: 75.

Wang CY, Li S. Clinical characteristics and

prognosis of 2887 patients with hepatocellular

carcinoma: A single center 14 years experience

from China. Medicine (Baltimore). 2019. 98:

e14070.

Jiang JF, Lao YC, Yuan BH, Yin J, Liu X, Chen

L, et al. Treatment of hepatocellular carcinoma

with portal vein tumor thrombus: advances and

challenges. Oncotarget. 2017. 8: 33911-33921.

Cerrito L, Annicchiarico BE, Iezzi R, Gasbarrini

A, Pompili M, Ponziani FR. Treatment of

hepatocellular carcinoma in patients with portal

vein tumor thrombosis: Beyond the known

frontiers. World J Gastroenterol. 2019. 25:

-4382.

Published 03-12-2021
Fulltext
PDF (Tiếng Việt)     134    33
Language
Issue No. 74 (2021)
Section Original article
DOI 10.38103/jcmhch.2021.74.6
Keywords Ung thư biểu mô tế bào gan, nút mạch hóa chất, mRECIST Hepatocellular carcinoma, transarterial chemoembolization, mRECIST

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2021 Journal of Clinical Medicine Hue Central Hospital

Linh, N. T. T., Dung, H. A., Hanh, H. T. N. H., An, N. D. H., Tuan, L. M., Hung, D. Q., … Binh, L. T. (2021). Đánh giá đáp ứng điều trị ung thư biểu mô tế bào gan sau nút mạch hóa chất (TACE) theo mRECIST. Journal of Clinical Medicine Hue Central Hospital, (74), 34–39. https://doi.org/10.38103/jcmhch.2021.74.6