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Abstract
INTENSITY-MODULATED RADIATION THERAPY WITH CONCURRENT CHEMOTHERAPY FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA
Pham Nguyen Tuong
Objective: To evaluate some characteristics of patients, treatment outcome, acute and late toxicities in head and neck squamous cell carcinoma (HNSCC) patients treated with intensity modulated radiotherapy (IMRT) with concurrent chemotherapy.
Materials and methods: Aprospective descriptive study of 87 nonmetastatic HNSCC patients performed IMRT concurrently with four to six cycles of cisplatin (30mg/m2/day/weekly) between May 2017 and May 2018. The total dose to primary tumour and neck lymph nodes was 70 Gy. All patients were evaluated
for tumour and node response using Response Evaluation Criteria In Solid Tumour (RECIST), acute and late toxicities according to CTCAE version 3.0 (Common Terminology Criteria for Adverse Events) and RTOG/ EORTC (Toxicity criteria of the Radiation Therapy Oncology Group/the European Organization for Research and Treatment of Cancer).
Results: The common response rates at the endpoint of treatment for primary tumour and lymph node respectively were 85.1% và 93.3%, in which complete response rates for tumour and lymph node were 44.9% and 64.4%, respectively. Those rates after 3 months, 6 months and 12 months were 44.9%- 66.1%,
- %- 62.7% và 44.8%- 62.7%. 18 patients died after 12 months, accounting for 20.7%. Acute toxicities were oral mucositis, dermatitis and nausea/vomiting mainly at grade 1. Grade 3 late toxicities were xerostomia 6/87(6.7%). There was no grade 3 to grade 4 neck fibrosis and trismus,3 patients developed grde 1 mandibularbone necrosis (3.4%).
Conclusion: Concurrent chemoriation therapy with IMRT provided excellent tumour response, manageable toxicities
Keywords: intensity-modulated radiation therapy, concurrent chemoradiation therapy, head and neck squamous cell carcinoma, response, toxicity.
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