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Abstract
Background: Acute kidney injury is one of the serious conditions in hospitalized patients. Acute kidney injury can develop early from the time of admission, usually occurring within the first 24 hours of ICU admission. In Vietnam, there are not many studies to monitor the progression of acute kidney injury in the early stages. This study aims to investigate the rate, extent, some clinical, subclinical characteristics and progression of acute kidney injury in patients with sepsis and septic shock in the first 48 hours.
Methods: A cross - sectional descriptive study on 101 patients over 15 years old diagnosed with severe infection and septic shock treated at the Intensive Care Unit - Hue Central Hospital. The patient was treated according to the protocol, followed up, took samples for testing, and monitored the amount of urine and blood creatinine.
Results: The AKI rate was60.40%, stage 1 accounted for 50.82%, stage 2 accounted for 22.95%, stage 3 accounted for 26.23%. Patients are older, mean 60.72 ± 17.41, mostly male. Patients with AKI had a lower urine volume and a higher rate of shock (p < 0.05), lower Hct, blood pH, HCO3- and higher blood urea, blood creatinine, AST, ALT, total bilirubin, PCT, blood lactate than patients without AKI (p < 0.05). AKI patients had higher SOFA and APACHE II scores than patients without AKI (p < 0.05). 81.97% of patients developed AKI right at the time of admission, recovered early in the first 24 and 48 hours.
Conclusion: The rate of AKI was 60.40%, stage 1 accounted for 50.82%, stage 2 accounted for 22.95%, stage 3 accounted for 26.23%. There are differences in urine volume, shock rate. AKI patients had higher SOFA and APACHE II scores. 81.97% of patients developed AKI at the time of admission, recovered early in the first 24 and 48 hours.
Keywords: Severe infection, septic shock, acute kidney injury
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| Published | 09-01-2025 | |
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| Issue | No. 85 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.85.5 | |
| Keywords | Từ khóa: Nhiễm khuẩn huyết, sốc nhiễm khuẩn, tổn thương thận cấp Keywords: Severe infection, septic shock, acute kidney injury |
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