Downloads
Abstract
Vitamin D metabolites and analogs are known to play an important role in the development and prevention of bone mineral diseases and bony fractures. However, vitamin D is involved in a variety of cellular processes including innate immunity, cell proliferation, differentiation, and apoptosis. There have been a variety of studies investigating the role of vitamin D in the risk of developing cancer, particularly colorectal cancer. Many mechanistic studies show that the active vitamin D metabolite (1α,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor via the regulation of a high number of genes. A key action underlining this effect is the multilevel inhibition of the Wnt/β-catenin signaling pathway, whose abnormal activation in colon epithelial cells initiates and promotes colorectal cancer. Calcitriol modulates gene expression and inhibits protumoral properties of patient-derived colon cancer-associated fibroblasts. High vitamin D receptor expression in tumor stromal fibroblasts is associated with longer survival of colorectal cancer patients. Moreover, many types of immune cells express vitamin D receptor and are regulated by calcitriol, which probably contributes to its action against colorectal cancer. Vitamin D also affects the gut microbiota that given the role attributed to the intestinal microbiota in colorectal cancer.
References
Augsten M. (2014), “Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment”, Frontiers in oncology. 4, pp. 62-62.
Barbáchano A. et al. (2018), “Chapter 99 - Vitamin D and Colon Cancer”, Vitamin D (Fourth Edition). David Feldman, Academic Press: 837-862.
Barry E. L. et al. (2017), “Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial”, JAMA oncology. 3 (5), pp. 628-635.
Berger M. D. et al. (2018), “A polymorphism within the vitamin D transporter gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab or FOLFIRI/cetuximab”, Clinical cancer research. 24 (4), pp. 784-793.
Dankers W. et al. (2017), “Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential”, Frontiers in immunology. 7, pp. 697- 697.
Dzutsev A. et al. (2017), “Microbes and Cancer”, Annual Review of Immunology. 35 (1), pp.
-228.
Fekrmandi F. et al. (2015), “The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits”, Scientific reports. 5, pp. 13002-13002.
Ferrer-Mayorga G. et al. (2017), “Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer”, Gut. 66 (8), pp. 1449-1462.
Ferrer-Mayorga G. et al. (2019), “Mechanisms of action of vitamin D in colon cancer”, The
Journal of Steroid Biochemistry and Molecular Biology. 185, pp. 1-6.
He L. et al. (2017), “Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis”, Endocrinology. 159 (2), pp. 967-979.
Jiang X. et al. (2018), “Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels”, Nature communications. 9 (1), pp. 260-260.
Liu Y. et al. (2018), “The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in
colorectal cancer”, Molecular cancer. 17 (1), pp. 11-11.
Öhlund D. et al. (2014), «Fibroblast heterogeneity in the cancer wound», The Journal
of experimental medicine. 211 (8), pp. 1503- 1523.
Protiva P. et al. (2016), “Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial”, The American journal of clinical nutrition. 103 (5), pp. 1224-1231.
Vaughan-Shaw P. G. et al. (2017), “The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis”,
British journal of cancer. 116 (8), pp. 1092-1110.
Wang J. et al. (2016), “Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota”, Nature genetics. 48 (11), pp. 1396- 1406.
Xu M. et al. (2018), “MiR-22 suppresses epithelial–mesenchymal transition in bladder cancer by inhibiting Snail and MAPK1/Slug/vimentin feedback loop”, Cell Death & Disease.
(2), pp. 209
| Published | 09-01-2025 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | No. 60 (2020) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2020.60.15 | |
| Keywords | vitamin D, ung thư đại trực tràng vitamin D, colorectal cancer |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2020 Journal of Clinical Medicine Hue Central Hospital