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Abstract
Cytogenetic variables in pediatric acute lymphoblastic leukemia (ALL) plays an important role in prognosis and risk grouping. Evaluation of early result treatment based on cytogenetic mutations provides data for physicians in treatment options for pediatric patients.
Objectives: Study on characteristics of chromosomal abnormalities and evaluate the relationship with the early result of treatment according to FRALLE 2000 protocol at the National Institute of Hematology and Blood Transfusion.
Subjects and research methods: This was a prospective study conducted on 188 pediatric ALL patients who were treated at the National Institute of Hematology and Blood Transfusion from August 1, 2016 to August 1, 2019.
Results: The incidence of chromosomal abnormalities in pediatric ALL patients was 13.8%. Structural abnormalities were more common (57.7% of structural abnormalities alone, 15.4% combined with structural and numberal abnormalities, 26.9% of numberal abnormalities alone). The most common structural abnormality was chromosomal translocations, in which t(9;22) was the most common. Hyperdiploid accounted 90.9% in the abnormal number of chromosomes. The poor prognosis group accounted for a higher proportion in the study. The good prognosis chromosome group had the best treatment results (Overal Survival - OS 12 months reached 100%, Event Free Survival - EFS 12 months reached 80.0 ± 17.9%). The group with the poor prognosis of chromosome: OS 12 was only 66.0 ± 11.3%, EFS 49.4 ± 12.2%. The difference was statistically significant with p <0.01. The normal chromosome group had good OS and EFS for 12 months, 90.4 ± 2.6% and 77.9 ± 3.6%, respectively.
Conclusion: The rate of abnormalities chromosome was low. Structural mutations were more common. Hyperdiploid was mainly seen on numberal chromosome abnormalities. This study found the difference in survival time between the groups according to the chromosome prognosis.
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| Published | 21-12-2020 | |
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| Issue | No. 66 (2020) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2020.66.12 | |
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