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Abstract
Background: Sepsis is the first reason of acute kidney injury (AKI) and AKI is also the frequent complication of sepsis. Beside relating to mortality rate, patients still carry the risk of developing chronic kidney disease (CKD) and end - stage renal disease. This study aims to investigate the situation of acute kidney injury and the factors which relate to the AKI in patients with sepsis and septic shock.
Methods: Study subjects included all adults above the age of 18 years admitted to Intensive Care Unit, Hue central hospital with a diagnosis of sepsis and septic shock. Data were collected from the patient’s records and through the inteview of patients (if they could answer) or their relatives. Additionally, we reviewed the clinical characteristics and laboratory data of AKI in patients with sepsis and septic shock.
Results: The percentage of male patients was 72% and the age group 46 - 65 and over 65 accounted for the highest proportion, SOFA scores 2 - 4 took the majority of 40%, septic shock accounted for 36% of the study, the abdominal infectionaccounted for the highest rate with 56%, followed by pulmonary infection, kidney - urinary tract, skin - soft tissue with the percentage of 18%, 16%, 5%, respectively. 76% patients were treated with two types of antibiotics. Regarding the acute kidney injury status, the rate of AKI is 68%. Regarding the factors related to AKI, it can be seen that the relevant factors include: Age above 65, comorbidities and septic shock status. The mortality rate is highly 52%, of which the mortality rate in AKI patients is 61.7%.
Conclusion: Patients with sepsis and septic shock had a high rate of AKI progression with 68%. The main infection in the study group was from the gastrointestinal tract with 56%. Patients who are elderly, have comorbidities, and are in septic shock are at greater risk of AKI. The mortality rate in AKI patients is considerably high with 61.7%.
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| Published | 07-01-2025 | |
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| Issue | No. 79 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.79.20 | |
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