Abstract

Background: Early and accurate severity classification plays a crucial role in managing acute pancreatitis (AP). Procalcitonin (PCT), CRP, and D-Dimer are potential biomarkers, but limited studies have evaluated their combined predictive value in AP. The study aims to evaluate PCT, CRP, and D-Dimer levels within the first 48 hours of admission in AP patients and to determine the prognosis value of combining PCT with CRP and D-Dimer.

Methods: A cross-sectional study involving 60 AP patients diagnosed and treated at Cho Ray Hospital from August 2023 to March 2024.

Results: PCT was the strongest predictor of severity and mortality in AP (AUC=0.93). Adding D-Dimer and CRP did not enhance predictive accuracy compared to PCT alone (AUC for predicting severity and mortality were 0.82 and 0.75, respectively). Admission PCT levels ≥4.06 ng/mL effectively predicted severe AP with a sensitivity of 87.5% and specificity of 97.7%.

Conclusion: PCT is a reliable predictor of AP severity and outcomes.