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Abstract
Background: COVID-19 caused by SARS-CoV-2 virus is an unprecedented global pandemic affecting more than 200 countries worldwide. Clinical and subclinical symptoms of the disease are significant in diagnosing and determining the severity of the disease. Identified prognostic factors can help clinicians in predictor of disease severity, prompt intervention, and reduce mortality.
Methods: A retrospective was conducted on 300 COVID-19 patients who were isolated and treated at the COVID-19 Intensive Care Center Unit run by Hue Central Hospital in Ho Chi Minh City.
Results: In 300 COVID-19 patients, average age 57.33±17.75; BMI 23.14+4.89; SBP 127.97±20.74 mmHg; DBP 78.4±12.11 mmHg; Inflammation of the upper respiratory tract 48.3%. Background diseases (hypertension 37.3%, diabetes 18.3%, chronic lung disease 5.3%, coronary artery disease 4.7%); severity group 53.7%, severe group 6%, moderate group 23.3%, mild group 17%; oxygen therapy on hospital admission through mask 34%, canule 4%, CPAP 5.3%, HFNC 8.7%, invasive ventilation 12%; Increase or decrease in white blood cell count 45.6%. Decrease in blood platelet count 7.7%; increased blood glucose 76%; decrease pH 17.3%; PaO2 70.1±31.66 mmHg; PaCO2 65.39±27.8 mmHg; FiO2 77.93±22.69; PaO2/FiO2 65.39±27.8. There was a difference in the number of white blood cells (<0.001), platelets (0.016), D-dimer (<0.001), ferritin (0.011), CRP (0.006), blood glucose (0.038) in the severity group compared with mild-severe grouThreshold leukocyte ≥11.6 k/μl, platelets 191 k/μl, D-dimer ≥1164 ng/ml, ferritin ≥370.73 ng/ml, CRP ≥26 mg/l, blood glucose >7.47 mmol/l for predictor of severity in COVID-19 patients.
Conclusion: Identified prognostic factors (threshold leukocyte ≥11.6 k/μl, platelets 191 k/μl, D-dimer ≥1164 ng/ml, ferritin ≥370.73 ng/ml, CRP ≥26 mg/l, blood glucose >7.47 mmol/l) can help clinicians and policy makers in tailoring management strategies for patients with COVID-19 infectious disease while researchers can utilise our findings to develop multivariable prognostic models that could eventually facilitate decision-making and improve patient important outcomes.
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| Published | 05-01-2025 | |
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| Issue | No. 79 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.79.5 | |
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