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Abstract
Background: Metabolic syndrome refers to a cluster of cardiovascular risk factors including abdominal obesity, dyslipidemia, hypertension, and hyperglycemia. An effective detection of metabolic syndrome not only reflects the prediction risk of diabetes mellitus and cardiovascular diseases but also helps to plan for management strategy which could reduce the healthcare burden of the society. Recent studies aimed to compare the use of hemoglobin A1c (HbA1c) to fasting plasma glucose as the hyperglycemic component in metabolic syndrome diagnosis. This study aims to compare the use of HbA1c to fasting plasma glucose as the hyperglycemic component in metabolic syndrome diagnosis in the study subjects, and determine the cut off value of HbA1c for predicting metabolic syndrome in the study subjects.
Method: A cross-sectional study in 338 non-diabetic adult subjects for health examinations at International Medical Center at Hue Central Hospital. Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Parameters of waist circumference, systolic blood pressure, diastolic blood pressure, and biochemical (triglycerides, HDL-C, fasting blood glucose and HbA1c) were determined. Reciever operating characteristic curve were generated to assess sensitivity and specificity for different cut off value of HbA1c for predicting metabolic syndrome.
Results: The prevalence of metabolic syndrome (model 3: glucose hoặc HbA1c) was 43,8% (148 subjects) higher than the prevalence of metabolic syndrome (model 1: glucose) was 36,7% (124 subjects) (p < 0,05). The optimal cut off point for HbA1c for predictor of metabolic syndrome as 5,5 (AUC: 0,756, sensitivity: 72,3%, specificity: 71,6%).
Conclusion: This study suggests that a potential role of HbA1c might be used as a diagnostic criterion for metabolic syndrome.
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| Published | 05-01-2025 | |
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| Issue | No. 79 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.79.4 | |
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