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Abstract
Objectives: Evaluation of mismatch repair protein expression status in some endometrial carcinoma patients in K hospital in the years of 2021 and 2022by immunohistochemical stains and recording some related clinical and pathological characteristics of those patients.
Methods: A cross - sectional study was conducted on 20 patients with endometrial carcinoma were oophorohysterectomy at Quansu High quality treatment Department, K hospital in 2021 and 2022.
Results: Percentage of MMRd was 40% (8/20 patients). The expression of these characteristics of MLH-1, MSH-2, MSH-6, PMS-2 were 20%, 5%, 5% and 35%, respectively. MMRd was not related to histological subtypes, grades and stages.
Conclusions: The rate endometrial carcinoma with MMRd is 40%. The study did not find a relationship between MMRd status and histopathological type, histological grade and stage of disease (p > 0.05).
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| Published | 20-01-2023 | |
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| Issue | No. 84 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.84.3 | |
| Keywords | Protein sửa chữa bắt cặp sai (MMR), mất biểu hiện protein sửa chữa bắt cặp sai (MMRd), mất ổn định vi vệ tinh (MSI), ung thư biểu mô nội mạc tử cung (UTBMNMTC), phân loại mô bệnh học, phân loại giai đoạn Mismatch repair protein (MMR), mismatch repair protein deficiency (MMRd), endometrial carcinoma, histopathological classification, tumor staging |
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