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Abstract
Background: The evaluation and classification of febrile seizures have a prognostic role because statistics show that approximately 30% of complex febrile seizures progress to epilepsy. However, most febrile seizures occur in the outpatient setting, and information on seizure characteristics for reclassification is usually obtained from the parent. The systemic inflammatory response has been implicated as a trigger for febrile seizures. Therefore, this is a scientific basis to study these test parameters as an objective index to classify febrile seizures.
Methods: A prospective observational study was conducted on 252 cases of patients diagnosed and treated at Pediatrics Center in Hue Central Hospital
Results: Median of neutrophil - lymphocyte ration (NLR), RDW, MPV for simple febrile seizure were 2,47 [1,59 - 3,76]; 15,40 [14,35 - 16,80]; 7,80 [7,20 - 8,70] and for complex febrile seizure were 3,30 [2,05 - 4,46]; 14,90 [14,00 - 16,30]; 7,50 [6,90 - 8,20]; respectively. The difference of NRL as well as MPV was significant (p < 0,05). We used receiver operating characteristic (ROC) analysis and chose a cutoff value of 2.786 for the NLR, the sensitivity and specificity were 64.49% and 58.62%, respectively (area under the curve [AUC]: 0.619, p = 0.001). The cutoff value for the MPV was 8,6; the sensitivity and specificity were 27,59% and 89,72%, respectively (AUC = 0,607; p = 0,004). Conclusions: We suggest that NLR and MPV may provide clinicians with an insight into differentiating between simple and complex febrile seizures.
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| Published | 20-01-2023 | |
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| Issue | No. 84 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.84.2 | |
| Keywords | MPV×, RDW, tỷ lệ bạch cầu neutro/lympho, phân loại co giật do sốt MPV, RDW, neutrophil-lymphocyte ratio, classification of febrile seizures |
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