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Abstract
Background: Acute lymphoblastic leukemia (ALL) is the most common malignant disease in children. Some genetic abnormalities have been recognized to have prognostic or therapeutic relevance. In this study, we aimed to analyze the clinical presentations, laboratory features, and genetic abnormalities in childhood acute lymphoblastic leukemia patients.
Methods: It was a descriptive cross - sectional, prospective study on childhood acute lymphoblastic leukemia patients who admitted to the hospital between April - 2018 and May - 2021.
Results: There were 58 new patients, the ratio of male to female was 1.64:1. The median age was 4.0 years (range: 0.66 to 15). The most common symptoms were anemia (82.8%), fever (74.1%), hepatomegaly (68.9%), splenomegaly (56.9%), enlarged lymph nodes (53.4%). Regarding laboratory features, 25.9% of the patients had white blood cell (WBC) ≥ 50 x 109/l, 82.8% patients had platelet (PLT) < 100 x 109/l, 79.3% patients had blood hemoglobin level (Hb) < 10 g/dl. Genetic analysis showed 22.4% patients have NUDT15 polymorphisms, 10.3% patients have TPMT polymorphisms, 13.7% patients have TEL/AML1, 3.4% patients have BCR - ABL, 3.4% patients have E2A/PBX1 and 1.7% patient have MLL/AF4.
Conclusions: The most common clinical presentations were anemia, fever, hepatosplenomegaly, bone pain and bleeding. NUDT15 and TPMT polymorphisms guide to adjust 6MP dose, reduce toxicities and side effects for patients.
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| Published | 09-08-2022 | |
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| Issue | No. 82 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.82.5 | |
| Keywords | Bạch cầu cấp dòng lympho, đột biến gen, trẻ em Acute lymphoblastic leukemia, children, genetic abnormalities |
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