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Abstract
Background: Intracranial germ cell tumors (IGCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. Depending on markers and/or histological characteristics, patients are treated as either germinoma or non-germinomatous germ cell tumors. The combination of surgery and/or chemotherapy and radiation therapy is tailored according to grouping and staging.
Methods: A retrospective and prospective study was conducted on 37 children with IGCTs who had been treated and followed up at Children National Hospital from 01/2016 to 08/2023.
Results: Complete response in geminoma IGCTs accounted for 45,5%, higher than nongeminomatous IGCTs at 30,8%. The overall survival rate (OS) and event-free survival rate (EFS) of geminoma IGCTs was 80% and 79.2%, respectively, which was higher than those of nongeminomatous IGCTs at 39.9% and 37.6%, with p = 0.02 and p = 0.01. The most common toxicities included neutropenia, thrombocytopenia, anemia, endocrine failure, hearing loss. Manifest in nongeminomatous was more than geminoma IGCTs.
Conclusions: Geminoma IGCTs had better responding and prognosis than nongeminomatous IGCTs.
Keywords: Intracranial germ cell tumors, children, treatment.
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| Published | 01-01-2025 | |
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| Issue | Vol. 16 No. 6 (2024) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.16.6.10 | |
| Keywords | Từ khóa: U tế bào mầm nội sọ, trẻ em, điều trị. |
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