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Abstract
Background: Liver is highly sensitive to hemodynamic changes. Heart failure can cause liver damage, which is a poor prognosis factor and complicate treatment. Elastography is a newly developed, noninvasive method for assessing liver stiffness. Some studies have suggested that liver stiffness is related to congestion status and central venous pressure in patients with heart failure. This study aims to investigate liver stiffness in patients with heart failure with reduced ejection fraction. Assess the correlation between liver stiffness measured by elastography and clinical features in patients with heart failure with reduced ejection fraction.
Methods: A cross-sectional descriptive study was conducted on 56 patients with heart failure with reduced ejection fraction who were treated at Internal Cardiology Department – Cardiology Center – Hue Central Hospital from March 2020 to August 2021.
Results: Male and female ratio was about 1,67/1; average age was 67,48 (± 13,47); the mean left ventricular ejection fraction was 28,8 ± 6,7; mean liver stiffness was 9,1 ± 7,1, median was 6,25 (interquartile range 5,4-9,7). The mean liver stiffness in our study was higher than the population mean value, the difference was statistically significant (p < 0,001). According to the Metavir classification, there were 39,29% of patients had liver fibrosis (liver stiffness ≥ 7,1) and 19,64% of patients with cirrhosis (liver stiffness >12,4). Liver stiffness were positively correlated with NT-proBNP (r = 0,433, p = 0,01), FIB-4 index (r = 0,465, p < 0,001), APRI index (r = 0,458), p < 0,001), PAPs (r = 0,385, p = 0,003), duration since heart failure diagnosed (r = 0,489, p = 0,023); were negatively correlated with eGFR (r = -0,284, p = 0,036); There was a statistically significant difference in liver stiffness between groups according to NYHA levels (p = 0,006).
Conclussion: Elastography is a promising method in assessing liver damage and systemic congestion status in patients with heart failure and maybe have a predictive value in patients with heart failure with reduced ejection fraction.
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| Published | 30-12-2024 | |
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| Issue | No. 79 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.79.2 | |
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