Downloads
Abstract
Objective: Urinary CD80 is recently considered a valuable marker in differentiating treatment responsiveness and identifying minimal change disease (MCD). Therefore, we conducted a survey on the urinary CD80 concentration and investigated the relationship between the urinary CD80 concentration and the histopathological forms of primary nephrotic syndrome (NS) in children.
Materials and method: A cross - sectional descriptive study in 60 children with NS with renal biopsy and 30 children in the control group.
Results: We found that: the urinary CD80/creatinine concentration in the NS with minimal change disease (MCD) was 25.73 (5.42 - 41.54) pg/ µmol, that of the NS non - MCD was 3.64 (1.92 - 9.56) pg/ µmol, that of NS with focal segmental glomerulosclerosis (FSGS) was 3.54 (1.79 - 6.01) pg/ µmol, and that of the control group was 2.67 (1.38 - 10.04) pg/ µmol. The concentration of CD80/creatinine in the urine in the NS with MCD group was significantly higher than that in the NS non - MCD group, NS with FSGS, and the control group (p < 0.05). The area under the ROC curve of urinary CD80/creatinine concentration for the diagnosis of MCD compared with other histopathologic forms was 0.82 (95% CI (0.71 - 0.93) at the cut - off point of 4.41 pg/µmol with a sensitivity of 93% and a specificity of 63%, a positive predictive value (PPV) of 89%. The area under the ROC curve of urinary CD80/creatinine concentration for the diagnosis of MCD compared with FSGS was 0.88 (95%CI (0.79 - 0.97) at the cut - off point of 14.78 pg/µmol with a sensitivity of 63% and a specificity of 100%, a PPV of 100%.
Conclusion: Urinary CD80/creatinine concentration was useful to differentiate the nephrotic syndrome with minimal change disease from other histopathologic forms.
References
ISKDC. Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney Int. 1978;13(2):159-65.
Reiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004;113(10):1390-7.
Garin EH, Mu W, Arthur JM, et al. Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney International. 2010;78(3):296-302.
Ling C, Liu X, Shen Y, et al. Urinary CD80 levels as a diagnostic biomarker of minimal change disease. Pediatr Nephrol. 2015;30(2):309-16.
Ahmed HM, Ezzat DA, Doudar NA, et al. Urinary CD80 as a Replacement for Renal Biopsy for Diagnosis of Pediatric Minimal Change Disease. Iran J Kidney Dis. 2018;12(2):107-111.
Gonzalez Guerrico AM, Lieske J, Klee G, et al. Urinary CD80 Discriminates Among Glomerular Disease Types and Reflects Disease Activity. Kidney Int Rep. 2020;5(11):2021-2031.
Niaudet P. Etiology, clinical manifestations, and diagnosis of nephrotic syndrome in children. Uptodate.com. 2020.
Sáng NV. Đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị hội chứng thận hư tiên phát trẻ em tại bệnh viện sản nhi Bắc Giang. Tạp chí Khoa học & Công nghệ. 2018;187(11):tr. 9-12.
Anochie I, Eke F, Okpere A. Childhood nephrotic syndrome: change in pattern and response to steroids. J Natl Med Assoc. 2006;98(12):1977-81.
Anh Trần Thị Kim Anh TNNU, Vũ Huy Trụ Khảo sát đặc điểm các trường hợp sinh thiết thận tại bệnh viện Nhi đồng 2. Tạp chí y học thành phố Hồ Chí Minh. 2021;2(25):tr. 14-20.
Trụ VH. 52 trường hợp hội chứng thận hư nguyên phát tại bệnh viện nhi đồng I. Tạp chí y học thành phố Hồ Chí Minh. 2003;7:tr. 119-122.
Kumar J, Gulati S, Sharma AP, et al. Histopathological spectrum of childhood nephrotic syndrome in Indian children. Pediatr Nephrol. 2003;18(7):657-60.
Loan HT. Sinh thiết thận tại bệnh viện Nhi đồng 1. Tạp chí Y học thực hành. 2010;10(739):tr.99-105.
Ð.c Nguy.n Th. H.ng Ð.c TKH, Nguy.n Th. Di.m Chi, Nguy.n Ð.nh Cân, Nguy.n Hoàng Minh, Hu.nh Ng.c Linh, Ph.m Nguyên Cý.ng. Nghiên c.u ð.c ði.m t.n thýõng mô b.nh h.c trong b.nh c.u th.n tr. em. T.p chí N.i ti.t và Ðái tháo ðý.ng. 2020;43:tr.78-83.
Souilmi F, Houssaini T, Alaoui H, et al. Indications and results of renal biopsy in children: A single-center experience from Morocco. 2015;26(4):810-815.
Lee SA, Kim MS, Kim SC, et al. Clinical and Pathological Findings of Renal Biopsy in Children: Outcomes from a Single Center Over 27 Years. Child Kidney Dis. 2017;21(1):8-14.
Shimada M, Araya C, Rivard C, et al. Minimal change disease: a “two-hit” podocyte immune disorder? Pediatr Nephrol. 2011;26(4):645-9.
Garin EH, Reiser J, Cara-Fuentes G, et al. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. Pediatr Nephrol. 2015;30(3):469-77.
Isom R, Shoor S, Higgins J, et al. Abatacept in Steroid- Dependent Minimal Change Disease and CD80-uria. Kidney International Reports. 2019;4(9):1349-1353.
| Published | 29-12-2024 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | No. 80 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.80.10 | |
| Keywords | Hội chứng thận hư, tổn thương tối thiểu, CD80 niệu Nephrotic syndrome, minimal change disease, CD80 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2022 Journal of Clinical Medicine Hue Central Hospital