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Abstract
Background: Prediabetes and hypertension may be comorbidities. This study aimed to identify and compare HOMA2-IR in the group of prediabetes with hypertension with the group of prediabetes without hypertension, and to analyze the correlation between HOMA2-IR and BMI in the prediabetics with hypertension.
Methods: The cross-sectional study included 95 prediabetes patients without hypertension and 96 prediabetes patients with hypertension between February 2023 and September 2023 at Cho Ray Hospital. Insulin resistance was determined using the HOMA2 model. Prediabetes and hypertension were diagnosed by ADA 2022 and ISH 2020 criteria, respectively.
Results: The analyzed data included 89 non-hypertensive prediabetics and 90 hypertensive prediabetics. HOMA2-IR (Median [IQR]) in the prediabetes with hypertension was 1.56 (0.97 - 2.28), which in the prediabetes without hypertension was 1.27 (0.87 - 1.95), p = 0.051. In the prediabetics with hypertension, univariate analysis showed that HOMA2-IR was statistically significantly correlated with sex and BMI; the results of the multivariate analysis showed that only BMI had a statistically significant correlation with HOMA2-IR. There was a moderate positive correlation between BMI and HOMA2- IR, which was statistically significant, r = 0.39, p < 0.001.
Conclusions: HOMA2-IR did not differ between the prediabetics with and without hypertension. There was a moderate positive correlation between BMI and HOMA2-IR, which was statistically significant, r = 0.39, p < 0.001.
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| Published | 28-12-2024 | |
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| Issue | No. 94 (2024) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.94.5 | |
| Keywords | Tiền đái tháo đường, tăng huyết áp, đề kháng insulin, BMI, HOMA2 Prediabetes, hypertension, insulin resistance, BMI, HOMA2 |
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