Abstract

Background: Polygenic risk scores (PRS) for coronary artery disease (CAD) contribute significantly to cardiovascular risk stratification, but their correlation with anatomical coronary lesion severity in acute myocardial infarction (AMI) have not been clarified yet. This study aims to describe baseline characteristics and stratify polygenic risk scores in patients with acute myocardial infarction; and to assess the correlation between polygenic risk scores and coronary artery lesion severity evaluated by invasive coronary angiography.

Methods: A cross-sectional study was conducted on 30 AMI patients undergoing coronary angiography and PRS profiling. Correlations between PRS and angiographic characteristics were analyzed and stratified by age (< 50 vs. ≥ 50 years).

Results: PRS distribution showed 73.3% borderline, 3.3% intermediate, and 23.3% high risk. In patients aged < 50 years (n = 20), PRS was significantly and positively correlated with the number of diseased vessels (r = 0.534; p = 0.015), culprit lesion length (r = 0.568; p = 0.009), and SYNTAX I score (r = 0.540; p = 0.014). These positive correlations were not found in patients aged ≥ 50 years.

Conclusions: Higher PRS is significantly associated with greater extent, length, and complexity of coronary artery lesions in young patients (< 50 years) presenting with AMI