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Abstract
Background: The serum of hs-Troponin T, which is recommended for routine clinical use, has a very high prognostic value for the degree of coronary artery damage in patients with acute coronary syndrome. Meanwhile, high - sensitive CRP level (hs- CRP) is a well - known protein in the acute phase of inflammation and have been shown to be associated with arteriosclerosis, including coronary arteries. Therefore, we conducted this study with the goal of understanding the correlation between hs- Troponin T and hs-CRP serum levels with coronary artery damage in patients with acute coronary syndrome.
Methods: A cross - sectional descriptive study of 86 patients diagnosed with acute coronary syndrome with indications for coronary angiography and intervention at the Department of Emergency and Interventional Cardiology - Cardiovascular Center - Hue Central Hospital from June 2020 to May 2022.
Results: The mean age was 66.94 ± 10.61. The concentrations of hs-Troponin T and hs-CRP in our study were 0.86 ± 1.55 ng/mL and 9.33 ± 11.5, respectively. Low SYNTAX score accounted for the highest percentage. The mean SYNTAX score in the study was 16.5 ± 7.5. There was an association between hs-Troponin T, and hs-CRP with the degree of coronary artery damage according to the SYNTAX score with p < 0.01. There was a positive correlation between the mean levels of hs-Troponin T, and hs-CRP with the degree of coronary artery damage according to the SYNTAX score with p < 0.01 and r were +0.387, and +0.471, respectively. The area under the curve (ROC) AUC of hs-Troponin T concentration value of 0.701 with a cut - off point of 0.109 ng/mL predicted intermediate and high SYNTAX score, with a sensitivity of 76 % and specificity 59% while the area under the curve (ROC) AUC of hs-CRP concentration value was 0.770 with a cut-off point of 8.52 mg/L predicted intermediate and high SYNTAX score, with a sensitivity of 68% and a specificity of 80.3%.
Conclusions: The levels of hs-troponin T and hs-CRP had a moderate positive correlation with the degree of coronary artery damage according to the SYNTAX score in patients with acute coronary syndrome. While hs-troponin T levels had higher sensitivity but lower specificity in predicting moderate and high SYNTAX score in patients with acute coronary syndromes as compared to hs-CRP levels.
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| Published | 28-12-2024 | |
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| Issue | No. 89 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.89.6 | |
| Keywords | Hội chứng vành cấp; thang điểm SYNTAX; troponin T siêu nhạy; CRP siêu nhạy. Acute coronary syndrome, SYNTAX score, high - sensitive troponin T, high - sensitive CRP |
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