Evaluation of the efficacy and safety of concurrent chemoradiation by Paclitaxel - Carboplatin regimen in stage III non - small cell lung cancer at K hospital

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Abstract

Objective: Evaluation of the efficacy and safety of concurrent chemoradiation by Paclitaxel - Carboplatin (PC) regimen in inoperable stage III non - small cell lung cancer
Methods: Restrospective descriptive study. 41 patients with inoperable stage III non - small lung cancer received 5 PC cycles (weekly Paclitaxel 45mg/m2 and Carboplatin AUC 2) with thoracic radiation therapy 60 - 66Gy. Overall response rate (ORR), progression - free survival (PFS), side effects of regimen were identified.
Results: From january 2018 to july 2019, 41 patients were enrolled in the trial. 71,7 % patient no longer or remision of symptoms after treatment. Response rate was 65,7%. Disease control rate was 85.4% Median progression - free survival was 11 months. The side effects of regimen was low and mostly grade 1 and 2 including fatigue anorexia, nausea and vomiting, esophagitis, leukopenia, neutropenia. These percentages were 60,9%, 53,6% 43.9%, 26.8%, 21.9% respectively.
Conclusion: PC regimen with thoracic radiation therapy in inoperable stage III non - small cell lung cancer is effective and safe

https://doi.org/10.38103/jcmhch.88.11

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Published 28-12-2024
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Issue No. 88 (2023)
Section Original article
DOI 10.38103/jcmhch.88.11
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Thang, T., Huy, N. V., & Hoa, N. T. (2024). Evaluation of the efficacy and safety of concurrent chemoradiation by Paclitaxel - Carboplatin regimen in stage III non - small cell lung cancer at K hospital. Journal of Clinical Medicine Hue Central Hospital, (88), 73–79. https://doi.org/10.38103/jcmhch.88.11