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Abstract
Background: Intracranial germ cell tumors (IGCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. Clinical presentations depend on primary location and size of tumor.
Methods: A cross - sectional descriptive, retrospective study was conducted on 50 children with IGCTs diagnosed at Children National Hospital during 01/2016 to 12/2022.
Results: The mean age of the disease is 8 ± 4.6 years old. The male/female ratio was 2/1. Common clinical symptoms were headache, vomiting and/or endocrine disturbances. Most cases were solitary tumours (92%). Tumor was located most commonly found in the pineal gland and/or suprasellar region. Non - germinomas accounted for 72% and germinoma - 28%. Non - germinoma IGCTs are larger in size, more ventriculomegaly condition, higher AFP, β - HCG level than germinoma IGCTs.
Conclusions: IGCTs in children had variable clinical manifestations depening on location, size and pathology of the tumor.
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| Published | 28-12-2024 | |
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| Issue | No. 90 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.90.13 | |
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