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Abstract
Background: Early - Onset Infection in Neonates (EOIN) is a disease with many difficulties in diagnosis, because symptoms of aforementioned disease are diverse, less specific, and can be encountered in non-infectious situations, leading to unnecessary antibiotic treatments. CRP and serum albumin are indicators of the presence and severity of neonatal sepsis. This study aims to understand the between CRP and serum albumin and the level of EOIN.
Methods: Newborns < 72 hours of age with suspected EOIN have at least 1 clinical symptom according to diagnostic criteria for EOIN of the Ministry of Health 2015. Evaluation of the EOIN level and taking CRP and serum albumin testing at the time of diagnosis.
Results: 90 patients with EOIN, including 18 cases of early-onset neonatal sepsis (EONS). Changes in serum albumin concentration accounted for the highest rate at 53.3%, followed by CRP at 37.8%. The rate of children with increased CRP in the EONS group (100%) was higher than the EOIN group (22.2%) (p < 0.05). The proportion of children with decreased serum albumin in the EONS group (77.8%) was higher than the EOIN group (47.2%) (p < 0.05). The median CAR in the EONS group (0.62) was higher than the EOIN group (0.11) (p < 0.05).
Conclusion: The combination between CRP and serum albumin is an independent predictor of the presence and severity of early-onset neonatal sepsis (EONS).
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| Published | 28-12-2024 | |
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| Issue | No. 90 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.90.11 | |
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