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Abstract
Background: Angiotensin - converting enzyme (ACE) gene plays an important role in pathology of lupus nephritis (LN) with renal failure. Our study aims to describe (1) Frequency of genotypes and allele I/D; (2) Correlation between I/D genotypes and clinical
features of LN patients without renal failure and with dialysis - requiring renal failure.
Methods: A descriptive cross - sectional study.
Results: From 12/2021 to 10/2022, there were 53 (52.5%) LN patients with dialysis - requiring renal failure (group 1) and 48 (47.5%) without renal failure with eGFR > 60ml/ph/1.73 m2 (group 2). The frequencies of II, ID, DD genotype were 0.396; 0.472; 0.132 (group 1); 0.646, 0.313, 0.042 (group 2), respectively. The frequencies of allele I, D were 0.632; 0.368 (group 1); 0.802, 0.198 (group 2), respectively. The risk of dialysis was increased in those with allele D (OR = 2.359; p = 0.008), DD (OR = 3.5; p = 0.111), ID + DD (OR = 2.779; p = 0.012). The dialysis rate was higher in DD as compared to II or ID (p < 0.05).
Conclusion: Allele D and genotype ID were predominant in LN patients with dialysis - requiring renal failure. Data of I/D polymorphism may contribute to the prognosis of such patients
References
Guan T, Liu Z, Chen Z. Angiotensin - converting enzyme gene polymorphism and the clinical pathological features and progression in lupus nephritis. Zhonghua Nei Ke Za Zhi. 1997;36(7):461-4.
Parsa A, Lovett DH, Peden EA, Zhu L, Seldin MF, Criswell LA. Renin - angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis. Genes Immun. 2005;6(3):217-24.
Molad Y, Gal E, Magal N, Sulkes J, Mukamel M, Weinberger A, et al. Renal outcome and vascular morbidity in systemic lupus erythematosus (SLE): lack of association with the angiotensin - converting enzyme gene polymorphism. Semin Arthritis Rheum. 2000;30(2):132-7.
Uhm WS, Lee HS, Chung YH, Kim TH, Bae SC, Joo KB, et al. Angiotensin - converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. Lupus. 2002;11(4):227-33.
Trần Thanh Tuấn, Lê Gia Hoàng Linh, Đỗ Đức Minh, Châu Ngọc Hoa. Khảo sát sự liên quan của biến thể gen ACE I/D với khối cơ thất trái ở bệnh nhân tăng huyết áp nguyên phát. Y học Thành phố Hồ Chí Minh. 2020;24(1):219-225.
Trần Công Duy, Lê Gia Hoàng Linh, Đỗ Đức Minh, Châu Ngọc Hoa. Khảo sát mối liên quan của các biến thể gen AGT M235T, ACE I/D, AGTR1 A1166C với nhồi máu cơ tim cấp. Tim Mạch Học. 2018;20(5):93-99.
Shanmugam V, Sell KW, Saha BK. Mistyping ACE heterozygotes. PCR Method Appl. 1993;3(2):120-1.
Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Eng J Med. 1995;332(11):706-11.
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-612.
Annigeri RA, Ostermann M, Tolwani A, Vazquez-Rangel A, Ponce D, Bagga A, et al. Renal Support for Acute Kidney Injury in the Developing World. Kidney International Reports. 2017;2(4):559-578.
Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25(11):1271-7.
Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-2686.
Touma Z, Urowitz MB, Ibañez D, Gladman DD. SLEDAI- 2K 10 days versus SLEDAI-2K 30 days in a longitudinal evaluation. Lupus. 2011;167-70.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-2572.
Rigat B, Hubert C, Alhenc-Gelas F, et al. An Insertion/ Deletion Polymorphism in the Angiotensin I-converting Enzyme Gene Accounting for Half tha Variance of Serum Enzyme Levels. J Clin Invest. 1990;861343-1346.
Cho Y, Sautenet B, Rangan G, Craig JC, Ong ACM, Chapman A, et al. Standardised Outcomes in NephrologyPolycystic Kidney Disease (SONG-PKD): study protocol for establishing a core outcome set in polycystic kidney disease. Trials. 2017;18(1):560.
Topete-Reyes JF, Soto - Vargas J, Moran-Moguel MC, Dávalos-Rodríguez IP, Chávez-González EL G-dlTI, et al. Insertion/deletion polymorphism of the angiotensinconverting enzyme gene in lupus nephritis among Mexicans. Immunopharmacol Immunotoxicol. 2013;35(1):174-80.
Sprovieri SRS, Sens YAS. Polymorphisms of the reninangiotensin system genes in Brazilian patients with lupus nephropathy. Lupus. 2005;14356-362.
Pitipakorn U, Suwannalai P, Trachoo O, Rattanasiri S, Chitphuk S, Ngamjanyaporn P, et al. Angiotensinconverting enzyme gene polymorphism in Thai patients with systemic lupus erythematosus. Int J Rheum Dis. 2016;19693-699.
Sato H, Akai Y, Iwano M, Kurumatani N, Kurioka H, Kubo A, et al. Association of an insertion polymorphism of angiotensin - converting enzyme gene with the activity of systemic lupus erythematosus. Lupus. 1998;7(8):530-4.
Akai Y, Sato H, Iwano M, Kurumatani N, Kurioka H, Kubo A, et al. Association of an insertion polymorphism of angiotensin - converting enzyme gene with the activity of lupus nephritis. Clin Nephrol. 1999;51(3):141-6.
Zhou TB, Yin SS, Qin YH. Association between angiotensin - converting enzyme insertion/deletion gene polymorphism and end - stage renal disease susceptibility. J Renin Angiotensin Aldosterone Syst. 2014;15(1):22-31.
| Published | 28-12-2024 | |
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| Issue | No. 88 (2023) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.88.6 | |
| Keywords | Gen Angiotensin - converting enzyme, biến thể I/D (insertion/deletion), tính đa hình, viêm thận lupus, chạy thận nhân tạo Angiotensin - converting enzyme gene, insertion/deletion, polymorphism, lupus nephritis, hemodialysis |
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