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Abstract
Background: Although there are many alternative treatment options for epilepsy, including vagus nerve stimulation (VNS), surgery, and the ketogenic diet, antiepileptic drugs (AEDs) are always the first choice because they are easy to apply. Drug treatment is sometimes prolonged and may require large doses and drug combinations. Therefore, the adverse effects of antiepileptic drugs should be considered during treatment. One such effect is on calcium metabolism. Therefore, evaluating the impact on calcium concentration and child growth is necessary.
Methods: A prospective cohort study was conducted on 78 cases of patients diagnosed and treated for epilepsy at the Pediatric Center of Hue Central Hospital
Results: Whole blood Calcium concentrations in the Carbamazepine (CBZ) treatment group according to age group (0 - < 2 years old, 2 - < 6 years old and 6 - < 16 years old) after 9 months of treatment were 2.38 ± 0.02 mmol/l; 2.31 ± 0.02 mmol/l, 2.27 ± 0.01 mmol/l; The values decreased compared to normal parameters after 6 months of treatment, decreased compared to the group treated with only valproate acid (VPA) after 3 months of treatment. The difference is statistically significant p < 0.05.
Conclusions: Calcium screening test and growth assessment, especially height, should be performed at least every 3 months of treatment, especially in the CBZ treatment group.
References
Stafstrom CE, Carmant L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harb Perspect Med. 2015;5(6).
Burgoyne RD, Helassa N, McCue HV, Haynes LP. Calcium Sensors in Neuronal Function and Dysfunction. Cold Spring Harb Perspect Biol. 2019;11(5).
Alison M Pack, Elizabeth Shane. Antiseizure medications and bone disease. 2023 [cited 2023 09/02]; Available from:https://www.uptodate.com/contents/antiseizure medications-and-bone-disease.
Fisher RS, Cross JH, D’Souza C, French JA, Haut SR, Higurashi N, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia. 2017;58(4):531-542.
Zhu X, Wang K, Zhou Q, Guo W, Jia Y, Xu J. Age- and SexSpecific Pediatric Reference Intervals of Serum Electrolytes in Jilin Province of China Using the A Priori Approach. Am J Clin Pathol. 2020;154(5):708-720.
Arinta Atmasari, Masayu Rita Dewi, Aditiawati, Masagus Irsan Saleh. Duration and dose of antiepileptic drugs and serum calcium levels in children. Paediatr Indones. 2017;57(2):104-107.
Misra A, Aggarwal A, Singh O, Sharma S. Effect of carbamazepine therapy on vitamin D and parathormone in epileptic children. Pediatr Neurol. 2010;43(5):320-4.
Min L, Chunyan W, Biaoxue R. Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta analysis based on 14 studies. BMC Pediatr. 2020;20(1):97.
Lee HS, Wang SY, Salter DM, Wang CC, Chen SJ, Fan HC. The impact of the use of antiepileptic drugs on the growth of children. BMC Pediatr. 2013;13:211.
Maksoud HMA, El-Shazly SM, El Saied MH. Effect of antiepileptic drug (valproic acid) on children growth. Egyptian Pediatric Association Gazette. 2016;64(2):69-73.
| Published | 28-12-2024 | |
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| Issue | No. 94 (2024) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.94.3 | |
| Keywords | Canxi máu, thuốc chống động kinh Blood calcium, antiepileptic drugs |
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