Abstract

Background: Septic shock is the leading cause of mortality in intensive care units with a mortality rate of 40-60%. Central venous oxygen saturation (ScvO₂) and serum lactate concentration are two important indicators reflecting tissue oxygenation status and have prognostic value in septic shock.

Methods: A prospective observational study was conducted on 58 patients with septic shock according to Sepsis-3 criteria in the Intensive Care Unit, Hue Central Hospital, from April 2023 to July 2024. ScvO₂ and lactate were measured at admission (T₀) and after 24 hours (T₂₄). Receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were employed.

Results: The 28-day mortality rate was 51.7%. ScvO₂_T₂₄ demonstrated weak prognostic value (AUC=0,671, p<0,05) with a cutoff point of 69%. Lactate_T₂₄ showed moderate prognostic value (AUC=0,717, p<0,05) with a cutoff point of 3.0 mmol/L. SOFA_T₂₄ had the best prognostic value (AUC=0,830, p<0,001). Multivariate analysis identified ScvO₂_T₀ (OR=0,884, p<0,05) and SOFA_T₂₄ (OR=1,645, p<0,05) as independent prognostic factors.

Conclusion: ScvO₂ and serum lactate have value in predicting mortality, particularly when measured after 24 hours of resuscitation. SOFA_T₂₄ is the best prognostic tool.