Plasma cell rich rejection in liver transplant - rare case report and literature review

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Abstract

Plasma cell rich rejection (PCAR), formerly also known as plasma cell rich hepatitis or de novo autoimmune hepatitis. It is a form of dysfunction after liver transplantation that occurs in 3% to 5% of patients with liver disease without a previous history of autoimmune hepatitis. PCAR has a high risk of graft loss but is easily overlooked because it is a rare form of graft rejection, especially in pediatric liver transplantation. We report a case of PCAR after liver transplantation from a living donor with incompatible blood types.

https://doi.org/10.38103/jcmhch.93.15

References

Demetris AJ et al. 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection. American Journal of Transplantation. 2016; 16(10):2816-2835.

Aguilera I, Sousa JM, Gavilán F, Bernardos A, Wichmann I, and Nuñez-Roldán A. Glutathione S-transferase T1 mismatch constitutes a risk factor for de novo immune hepatitis after liver transplantation: GSTT1 Mismatch and Posttransplant Hepatitis. Liver Transpl. 2004;10(9):1166-1172.

Demetris AJ, Sebagh M. Plasma cell hepatitis in liver allografts: Variant of rejection or autoimmune hepatitis?. Liver Transplantation. 2008;14(6):750-755.

Fiel MI et al. Posttransplant plasma cell hepatitis (de novo autoimmune hepatitis) is a variant of rejection and may lead to a negative outcome in patients with hepatitis C virus. Liver Transplantation. 2008;14(6):861-871.

Harrington CR, Levitsky J. Alloimmune versus autoimmune hepatitis following liver transplantation. Clin Liver Dis (Hoboken). 2022;20(1):21-24.

Ozturk NB, Schiano TD, Fiel MI. Histologic and Clinical Outcomes of Patients Developing Post–Liver Transplant Plasma Cell–Rich Rejection. American Journal of Clinical Pathology. 2023;160(1):49-57.

Charlton M et al. International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients. Transplantation. 2018;102(5):727-743.

Furuya M et al. Plasma cell-rich rejection accompanied by acute antibody-mediated rejection in a patient with ABO-incompatible kidney transplantation. Nephrology. 2014;19(S3):31-34.

Abbas K et al. Plasma cell-rich acute rejections in living- related kidney transplantation: a clinicopathological study of 50 cases. Clinical Transplantation. 2015;29(9):835-841.

Published 10-12-2023
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PDF (Tiếng Việt)     82    53
Language
Issue No. 93 (2024)
Section Case report
DOI 10.38103/jcmhch.93.15
Keywords Thải ghép cấp, thải ghép cấp giàu tương bào Acute rejection, plasma cell rich rejection

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Copyright (c) 2024 Journal of Clinical Medicine Hue Central Hospital

Yen, P. T. H., Thach, H. N., Thuy, T. T., Duong, D. A., Hien, P. D., Cong, L. D., … Long, P. H. (2023). Plasma cell rich rejection in liver transplant - rare case report and literature review. Journal of Clinical Medicine Hue Central Hospital, (93), 87–91. https://doi.org/10.38103/jcmhch.93.15