Abstract

Objective: To evaluate the relationship between CA 125 levels and congestion, expressed through clinical and paraclinical aspects of patients with acute decompensated heart failure.

Methods: The study was conducted on 80 patients admitted to the Department of Cardiology - Hue Central Hospital from October 2024 to December 2024. These patients were divided into three groups: Group 1: 25 patients were calculated to have decompensated heart failure, Group 2: 31 patients with stable heart failure, hospitalized for other reasons, Group 3: 24 patients without heart failure. The study was conducted using a cross-sectional study method. The sampling method was convenient.

Results: CA 125 levels in the group of patients with acute heart failure was 126.2 ± 12.3 U/mL, significantly higher than that in the group of patients with chronic heart failure 17.6 ± 1.6 U/mL, and the group of patients without heart failure 11.2 ± 1.3 U/mL (p < 0.001). The group with clinical symptoms of acute heart failure at admission such as edema, jugular vein distention, dyspnea, and enlarged liver had significantly higher CA 125 concentration, so compared to the group without clinical manifestations of acute heart failure, the higher the NYHA classification, the higher the CA 125 (p < 0.05). There was a statistically significant positive correlation with p < 0.05 between CA 125 concentration at admission and biochemical indices CKMB, hs-TroponinT, Creatinine, Ure, NT-proBNP. In particular, NT-proBNP and CA 125 concentrations were positively correlated at admission and after 7 days of treatment with r-squared of 0.749 and 0.558 (p < 0.05).

Conclusion: CA 125 is a valuable test to assess congestion in patients with acute decompensated heart failure