Abstract
Background: The prolonged use of prednisone in the treatment of nephrotic syndrome caused secondary adrenal insufficiency due to the hypothalamic - pituitary - adrenal suppression.
Objective: to evaluate the functions of the adrenal gland and the factors involved in adrenal function by Synacthen (tetracosactide) test in pediatric nephrotic syndrome after prednisolone treatment attacks.
Methods: The study was performed on 30 patients with nephrotic syndrome who were treated by prednisolone 2mg/kg/day for at least 4 weeks.
Results: The rate of adrenal insufficiency: was 93.33%. There was no relationship between adrenal function with time of treatment and number of treatment (p>0.05). There was no relationship between blood cortisol levels 0 and 0' (p>0.05). There was a negative correlation between blood cortisol levels 0' and ratio cortisol 30'/cortisol 0' (rs = -0.875 p<0.05,.
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| Published | 07-09-2015 | |
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| Issue | No. 30 (2015) | |
| Section | Original article | |
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| Keywords | tuyến thượng thận, nghiệm pháp Synacthen adrenal glands, Synacthen test |
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