Study on Folate Concentration in Pregnant Women at Hue University of Medicine and Pharmacy Hospital

Downloads

Download data is not yet available.

Supplementary Files

PDF (Tiếng Việt)     18    0

Abstract

Objective: Measuring folate concentration, shortage level and related risks at pregnant women during the three pregnancy trimesters.
Research method: Designing descriptive study at 180 pregnant women who had health check at Huế College of Medicine and Pharmacy from July 2013 to April 2014.
Results: Average folate concentration was 8.82±4.83 (ng/mL). The percentage of pregnant women who lacked of folate in their blood was 8.3% (<3 ng/mL). The shortage risk was 28.9% (≥3-<6 ng/mL). The percentage of pregnant women who had anemia was 39.4%. Folate decreasing rate in the anemia group was 71.8%, which was higher than that of the group who did not have anemia (14.7%) (p<0.01). Folate concentration was correlated to: Hb, Hct, MCV, MCH, MCHC (p<0.01). The folate decreasing rate was correlated to family finance status (which is 64.7% at the group of pregnant women in poor family), number of carriage times (which is 60.9% at the group of pregnant women who have ≥4 times of carriage), process of taking multivitamin supplementation with acid folic (which is 84.2% at the groups of pregnant women who do not take multivitamin supplementation or who do take it but not frequently) (p<0.05). There was not correlation between the folate decreasing rate with age, geography, education, occupation, and pregnancy age (p>0.05).
Conclusion: It is common to have anemia at pregnant women (39.4%). There is a decrease of folate concentration (<6 ng/mL) with a high rate (37.2%). Average folate concentration is 8.82±4.83 (ng/mL), which is at a low level to compare with the other areas and world standard.

References

Phạm Thúy Hòa, Nguyễn Lân, Trần Thúy Nga (2000), “So sánh hiệu quả bổ sung viên sắt với acid folic hàng tuần và hàng ngày lên tình trạng thiếu máu của phụ nữ nông thôn trong thời kỳ có thai”, Tạp chí Y học dự phòng, 4 (46), tr. 24-29.

Cao Thị Thu Hương (2004), “Hiệu quả bổ sung đa vi chất lên tình trạng thiếu máu, thiếu vitamin A và thiếu kẽm của phụ nữ có thai huyện Thanh Oai, Hà Tây”, Tạp chí Y học Dự phòng, 1(65), tr. 88-92.

Nguyễn Viết Trung, Nguyễn Văn Nguyên (2003), “Nghiên cứu hàm lượng acid folic ở phụ nữ mang thai thiếu máu và không thiếu máu", Tạp chí Y Dược học Quân sự, 4, tr. 51-53.

Garcisa-Casal MN, Osorio C, Landaeta M, Leets I, Matus P, Fazzino F, Marcos E. (2005), "High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela", European Journal of Clinical Nutrition, 59, pp. 1064-1070.

Green TJ, Skeaff CM, Venn BJ, Rockell JE, Todd JM, Khor GL, Loh SP, Duraisamy G, Muslimatun S, Agustina R, Ling X, Xing X. (2007), "Red cell folate and predicted neural tube defect rate in three Asian cities", Asia Pac J Clin Nutr, 16(2), pp. 269-273.

Hien VTT, Lam NT, Khan NC, Dung NT, Skeaff CM, Venn BJ, Walmsley T, George PM, Lean JM, Brown MR, Green TJ. (2008), "Folate and vitamin B12 status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam", Public Health Nutrition, 12(7), pp. 941-946.

Kazmi S, Ayyub M, Ikram N, Iqbal S. (2013), "Red Cell Folate, Serum Vitamin B12 and Ferritin Levels During Pregnancy and their Correlation with Red Cell Indices", Journal of Rawalpindi Medical College (JRMC), 17(1), pp. 91-94.

Khan DA, Fatima F, Imran R, Khan FA. (2010), "Iron, folate and cobalamin deficiency in anaemic pregnant females in tertiary care centre at Rawalpindi", J Ayub Med Coll Abbottabad, 22(1), pp. 17-21.

Laillou A, Thuy Van Pham, Nga Thuy Tran, Hop Thi Le, Wieringa F, Rohner F, Fortin S, Mai Bach Le, Do Thanh Tran, Fanner RM, Berger J. (2012), "Micronutrient Deficits Are Still Public Health Issues among Women and Young Children in Vietnam", PLoS ONE, 7(4), pp. 34906.

Seshadri S. (2001), "Prevalence of micronutrient deficiency particularly of iron, zinc and folic acid in pregnant women in South East Asia", British Journal of Nutrition, 85(2), pp. 87-92.

WHO (2008). Worldwide prevalence of anaemia 1993-2005. WHO Global Database on Anaemia, World Health Organization, (http://whqlibdoc.who. int/publications/2008/9789241596657_ eng.pdf), pp. 1-8.

WHO (2012). Serum and red blood cell folate concentrations for assessing folate status in populations, World Health Organization, pp. 1-5.

Published 07-09-2015
Fulltext
Language
Issue No. 30 (2015)
Section Original article
DOI
Keywords Folate, thiếu máu Folate, anemia

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2025 Journal of Clinical Medicine Hue Central Hospital

Hoang Thi Thu Huong, & Lu Thi Thu Huyen, Nguyen Thi Thanh Binh, Nguyen Quynh Chau. (2015). Study on Folate Concentration in Pregnant Women at Hue University of Medicine and Pharmacy Hospital. Journal of Clinical Medicine Hue Central Hospital, (30), 79–88. Retrieved from https://jcmhch.com.vn/index.php/home/article/view/2216