Abstract
Background: The concentration of BNP and NT-proBNP significanting increases in diagnosis, prognosis in heart failure. They also increased in acute stage of cerebral hemorrhage.
Objective: to determine whether NT-proBNP concentrations increased in the acute cerebral hemorrhage and their relationship with the severity of the disease.
Subjects and Methods: A study on 30 patients with acute stage cerebral hemorrhage at the Department of Emergency, Hue Central Hospital. The patients were diagnosed based on clinical symptoms and CT scan images of the brain, NT-proBNP testing for 24-36h after admission and severity of illness based on the Glasgow scale and injury on cranial CT scan.
Results: The average concentration of NT-proBNP plasma in the research group was 485.36±396.87 pg/ ml, this concentration has increased significantly compared with the control group. There was a correlation between level of plasma NT-proBNP and the severity of cerebral hemorrhage. Plasma NT-proBNP concentration had positive correlation with systolic blood pressure (r=0.31) and diastolic blood pressure (r=0.21), had inverse correlation with Glasgow coma scale (r=−0.49) and blood sodium concentration (r=−0.15).
Conclusion: NT-proBNP concentrations is very high in the acute cerebral hemorrhage. It is related to a number of factors such as age, sex, Glasgow scale, the number of erythrocytes, hemoglobin, hematocrit, serum creatinine, blood glucose. However, the prognostic value of NT-proBNP should be studied further.
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| Published | 07-09-2015 | |
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| Issue | No. 30 (2015) | |
| Section | Original article | |
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| Keywords | NT-proBNP, xuất huyết não NT-proBNP, cerebral hemorrhage |
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