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Abstract
Objectives: To evaluate the results of hepatoblastoma treatment and the advances in the application of protocol SIOPEL 3 at the National Hospital of Pediatrics. Methods: descriptive cross-sectional series, longitudinal study with heptatoblastoma patients from 0 to 16 years old treated at the National Hospital of Pediatrics. Results: During the period from 01/01/2010 12/31/2013 at the National Hospital of Pediatrics, 46 hepatoblastoma patients were treated with protocol SIOPEL 3. Overall survival rate was 82.6% after the average follow-up period of 29.6 ± 15.3 months. Standard risk group had 3 year event-free survival of 89.1%, high risk group of 21.4%. Relapsed rate was 6.5% and the mortality rate was 17.4% due to progressive disease. Conclusion: hepatoblastoma is sensitive to chemicals, treatment outcomes for hepatoblastoma patients has made progress, particularly in standard risk groupReferences
Malogolowkin MH, K.H., Meyers RL, Krailo MD, Rowland JM, Haas J, Finegold MJ. (2011), Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group, Journal of Clinical Oncology, 29, pp. 3301-3306,
Joerg Fuchs, G.S., Rupert Handgretinger Steven W Warmann (2012), Extanded hepatic resection in advanced hepatoblastoma, Frontiers in Bioscience, E4, pp. 462-467.
Otte, J.-B. (2010), Progress in the surgical treatment of malignant liver tumors in children, Cancer Treatment Reviews, 36, pp. 360-371.
Trần Đức Hậu, PTL, TTH và cs (2007), Kết quả điều trị U nguyên bào gan tại khoa Ung bướu, Bệnh viện Nhi Trung ương từ 2002 - 2006, Tạp chỉ Nhi khoa, 15(1), pp. 46-54.
Zrioz J., Maibach R., Shafford E. et al. (2010), Successful Treatment of Chilhood High- risk Hepatoblastoma with Dose Intensive Multiagent Chemotherapy and Surgery: Final Results of the SIOPEL-3HR Study, Journal of Clinical Oncology, 29(15), pp. 2584-2590.
Perilongo G, Maibach R, Shafford E. et al (2008), Cisplatin versus Cisplatin plus Doxorubicin for Standard risk Hepatoblastoma, The New England Journal of Medicine, 361(7), pp. 1662-1670.
Otte Jean Bernard (2010), Progress in the surgical treatment of malignant liver tumors in children, Cancer Treatment Reviews, 36. pp. 360-371.
| Published | 03-03-2025 | |
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| Issue | No. 28 (2015) | |
| Section | Original article | |
| DOI | 10.38103.28.10 | |
| Keywords | hepatoblastoma |
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