Abstract

Objective: To survey on the clinical and paraclinical characteristics of Ewing's sarcoma at Oncology Hospital HCMC. Evaluate the outcome, side effects of the treatment regimen and the overall survival. Patients and methods: 19 patients s 16 years-old were diagnosed with Ewing's Sarcoma based on anapathology and immunohistochemistry. All of patients were treated at Oncology Hospital HCMC from 1/2009 to 12/2013. Results: The median age was 7.5 years (range 4 months old to 15 years old). Boy have a higher risk than girl, the proportion of male/female was 5.3/1. After initial symptoms, time to clinical diagnosis was 3.5 months. Primary tumors of bone accounted for 42.1%, 57.9% outside the bone, in which the majority of tumors in the limbs (47.4%), head and neck (21%), spinal cord (15.8%), other (15.9%). Ewing's sarcoma histological type (57.9%) 78.9% response chemotherapy in which complete response was 26,3%. Progression diseases or metastases after chemotherapy were relatively high (21.1%). The proportion of 2-year overall survival and 3-year overall survival were 33.1% and 56.3%. Conclusion: Primary tumors resection is an important factor to affect the outcome of treatment adjuvant (chemotherapy and radiotherapy). There is no difference in the level of response to chemotherapy factors such as: type of chemotherapy regimen, initial surgical approach, age group. Adjuvant radiation therapy improves local control after resection and chemotherapy. Several factors could adversely affect the outcome of survival, including: metastasis condition, the level of response to chemotherapy and radiotherapy.