Downloads
Abstract
Objective: To remark characteristics of clinical, subclinical, and results of chemotherapy on gestational trophoblastic neoplasia patients.
Methods: A retrospective combined prospective study was conducted on 36 women with low and high risks of gestational trophoblastic neoplasia from January 2015 to October 2020. The low - risk group was treated with methotrexate alone. The high - risk group was treated with EMA/CO (etoposide, methotrexate, actinomycin D/ leucovorin calcium, vincristine, cyclophosphamide).
Results: The most common age was > 40 years old. Patients admitted to the hospital because of vaginal bleeding accounted for the highest rate of 52.8%. Most of the patients (83.3%) had initial Beta - HCG < 100000. The most common histopathological form is choriocarcinoma, with 50%. Lung metastatic lesions accounted for the highest (53.8%). The proportion of low - risk and high - risk patients was about 50%. The complete response rate was 83,3% with the methotrexate regimen and was 83,3% with EMA/CO regimen. The proportion of patients with grade 3.4 toxicity accounted for a small proportion, mainly in hematology.
Conclusion: The regimens had good results, high response rates, and safety.
References
FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Committee on Gynecologic Oncology. Int. J. Gynecol. Obstet. 2002. 77:285-87.
Nguyễn Văn Trung (2011). Nghiên cứu kết quả điều trị ung thư nguyên bào nuôi sau đẻ tại bệnh viện Phụ sản trung ương. Luận văn tốt nghiệp bác sỹ chuyên khoa cấp II.
MpR. Treatment results of low risk gestational trophoblastic neoplasia (GTN) from a tertiary hospital, Chennai, India. Annals of Oncology.
1(3):ix87.
Khan F, J Everard, et al. Low - risk persistent gestational trophoblastic disease treated with lowdose methotrexate: efficacy, acute and long - term effects. Br J Cancer. 2003. 89(12): 2197-2201.
Hussain A, Aziz SA, et al. Management of gestational trophoblastic neoplasia. Clinical Obstetrics, Gynecology and Reproductive Medicine. 2015. 1(1): 5-11.
Alifrangis C, Agarwal R, Short Det al. EMA/CO for high - risk gestational trophoblastic neoplasia: good outcomes with induction lowdose etoposide - cisplatin and genetic analysis. J Clin Oncol. 2013.31: 280-286
TuranT, KaracayO, et. al. Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy
in gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2006.16(3):1432-8.
| Published | 02-03-2025 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | No. 76 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.76.5 | |
| Keywords | Bệnh u lá nuôi thời kỳ thai nghén, methotrexate, EMACO Gestational trophoblastic neoplasia, methotrexate, EMA/CO |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2022 Journal of Clinical Medicine Hue Central Hospital