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Abstract
Septic shock still carries a high mortality rate despite all advances in emergency
and critical care practices. Septic shock is characterized by systemic vasodilatation
and vascular leakage arising from systemic inflammation induced by serious infection.
Management, besides specific treatments consisting of antibiotics and source removal,
includes effective restoration of the hemodynamic derangement and effective organ
support. Generally, intravenous fluid is given first, followed by infusion of vasopressors
when the blood pressure goal is not achieved after reaching the optimal intravascular
volume. Early interventions have been proven in many aspects to improve outcome.
However, early administration of vasopressors namely norepinephrine in septic shock is
still controversial.As vasculartone depression is a hallmark of septic shock, administration
of norepinephrine is logical in this setting. This review provides the arguments for an
early use of norepinephrine - the recommended first-line vasopressor - in septic shock.
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| Published | 02-03-2025 | |
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| Issue | No. 87 (2023) | |
| Section | Review | |
| DOI | 10.38103/jcmhch.87.18 | |
| Keywords | Sử dụng norepinephrine sớm, quá tải dịch, nhiễm khuẩn huyết, sốc nhiễm khuẩn. Early norepinephrine, fluid overload, sepsis, septic shock |
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