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Abstract
Materials & methods: Prospective study on 54 patients with locally advanced stage of distal gastric
adenocarcinoma, underwent distal gastrectomy and D1 or D2 dissection, completed postoperative
chemoradiation therapy regimen at Oncology center of Hue Central Hospital from 01/2013 to 12/2015 and
followed up to August 30th, 2018.
Results: Mean age was 58.56 ± 10.28, male/female ratio: 2.6/1, the average time of recurrence
and metastasis were 21.33 ± 17.76 months and 14.64 ± 12.93 months, respectively. The mean overall
survival was 43.16 ± 2.91 months. The mean disease free survival was 40.17 ± 3.24 months. The mean
overall survival: stage IIA was 40.0 ± 3.3 months; stage IIB was 30.9 ± 3.6 months, stage III was 25.6 ±
6.0 months. The mean overall survival for extention of primary tumors: T2 was 38.1 ± 10.0 months , T3
was 45.5 ± 3.3 months; T4 was 31.3 ± 7.8 months. The mean overall survival for extensive of lymph nodes:
N (-) was 47.2 ± 3.4 months, N (+) was 33.9 ± 4.5 months. Toxicity levels recorded as follow: leukopenia
was mainly on grade 1 and 2 (46.3%), neutropenia was mostly on grade 1 and 2 (36.0%), as well as
thrombocytopenia (9.3%); hemoglobin decrease was on grade 1 and 2 in most cases (22.2%); toxicity
symptoms on digestive system like nausea-vomitting, diarrhea was mainly on grade 1 and 2.
Conclusion: Postoperative chemoradiation therapy helps to improve local and regional recurrence in
locally advanced gastric cancer with acceptable toxicities.
Key words: Distal gastric adenocarcinoma, postoperative chemoradiation therapy
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