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Abstract
Background: Chronic Spontaneous Urticaria (CSU) is a common condition. Autoimmunity is considered the underlying cause for the majority of CSU cases. The Autologous Serum Skin Test (ASST) demonstrates an autoreactive phenomenon and is one of the diagnostic criteria for autoimmune chronic urticaria. This study aimed to determine the prevalence of ASST positivity among CSU patients and to describe the clinical and laboratory characteristics of these patients.
Methods: A cross-sectional study was conducted on 388 patients aged 16 and above, diagnosed with CSU at the National Hospital of Dermatology and Venereology from June 2023 to March 2024. Data on demographics, medical history, treatment history, clinical symptoms, and laboratory findings were collected.
Results: The proportion of CSU patients with a positive ASST was 57.2%. Female patients were 1.74 times more likely to have a positive ASST than male patients (OR = 1.74; 95%CI = 1.05 - 2.89, p = 0.03). Patients with isolated CSU were 6.06 times more likely to have a positive ASST compared to those with concurrent chronic inducible urticaria (OR = 6.06; 95%CI = 2.88 - 12.76; p < 0.01). Patients with elevated SGOT levels were 0.30 times more likely to have a positive ASST compared to those with normal SGOT levels (OR = 0.30; 95%CI = 0.12 - 0.75; p = 0.01).
Conclusion: ASST is an important supplementary tool in assessing the autoimmune aspect of chronic urticaria and should be more widely utilized to guide effective treatment strategies.
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| Published | 20-10-2024 | |
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| Issue | Vol. 16 No. 7 (2024) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.16.7.18. | |
| Keywords | Mày đay, Mày đay mạn tính tự phát, Mày đay mạn tính tự miễn, ASST Urticaria, Chronic spontaneous urticaria, Autoimmune chronic urticaria, ASST |
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