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Abstract
Background: Early - onset neonatal infection is an important cause of morbidity and mortality in neonates and it’s diagnosis remains challenging. Therefore, this study aimed to describle the related factors that can help establish the diagnosis of early - onset neonatal infection.
Methods: A retrospective study. A total sample of 295 neonates at Hue University of Medicine and
Pharmacy Hospital, Hue, Viet Nam from 5/2019 - 5/2020, who were suspected to suffer from infection within the first 72 hours of life. Then, they were classified as infected group (confirmed or possible infected) and non - infected group to compare.
Results: The prevalence of infected group is 57,3%. Some related factors of early - onset neonatal infection are: prelabour rupture of membranes (OR=4,7), rupture of membranes for more than 18 hours (OR = 2,5), pale or mottled skin (OR = 14,9), need for mechanical ventilation (OR = 8,7), respiratory distress starting more than 4 hours after birth (OR = 6,8), responsiveness (OR = 6,6), abdominal distension (OR = 4,2), tachypnoea (OR = 2,7),vomiting (OR = 2,3), white blood cell in peripheral circulation > 25 x 109/L (OR = 5,7), neutrophil ratio in peripheral circulation > 65% (OR = 2,0) and CRP concentrations > 10 mg/L (OR = 8,0).
Conclusions: Combination of perinatal risk factors, clinical and subclinical characteristcs are highly suggestive for early - onset neonatal infection will help to reduce the numbers of babies given antibiotics unnecessarily.
Key words: Neonate, early - onset infection, perinatal risk factors
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| Published | 19-02-2025 | |
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| Issue | No. 71 (2021) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2021.71.15 | |
| Keywords | Sơ sinh, nhiễm khuẩn sơ sinh sớm, yếu tố nguy cơ trước sinh Neonate, early - onset infection, perinatal risk factors |
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