Downloads
Abstract
Objective: Survey of serum cystatin C levels and Glomerular Filtration Rate (GFR) from serum cystatin C in type 2 diabetic nephropathy. To examine the association between serum cystatin C levels, cystatin C-based estimated GFR and serum creatinine levels and creatinine-based estimated GFR. Subjects and methods: 88 patients with type 2 diabetic nephropathy were clinically examined and tested for serum creatinine, serum cystatin C, proteinuria, and microalbuminuria. Results: Serum cystatin C levels, cystatin C-based estimated GFR were strongly and significantly correlated to serum creatinine levels and creatinine-based estimated GFR in diabetic nephropathy patients, especially in patients with chronic renal failure. There was no significant correlation between the serum cystatin C levels, cystatin C-based estimated GFR with serum creatinine levels and creatinine-based estimated GFR in diabetic patients with creatinine-based estimated GFR ≥ 60, MAU (+). The rate of patients with renal failure evaluated by cystatin C-based estimated GFR was higher than the rate of patients with renal failure assessed by cystatin C-based estimated GFR. Conclusion: Cystatin C can be considered as an indicator of kidney function in type 2 diabetic nephropathy
References
Đặng Anh Đào (2019). Nghiên cứu mức lọc cầu thận bằng cystatin C huyết thanh ở bệnh nhân tiền đái tháo đường và đái tháo đường týp 2. Luận án Tiến sĩ.
Phạm Quốc Toản, Hoàng Trung Vinh, Nguyễn Văn Tiến (2015). Khảo sát mối liên quan giữa nồng độ cystatin C với huyết thanh và mức lọc cầu thận ở bệnh nhân đái tháo đường týp 2 có tổn thương thận. Y Dược học Quân sự, số 1, 56-62.
Byung-Wan Lee, Sung-Hee Ihm (2007). The comparison of as an accurate serum marker in the prediction of type 2 diabetic nephropathy. Diabetes Research and Clinical Practice, 78, 428-434.
Grubb A. (2011). Cystatin C as a biomarker in kidney disease. Biomarker in Kidney Disease, First Edition, 291-306.
KDIGO (2012). KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney International Supplements, 3(1), 19-62.
Leskey A. Inker, Christopher H. Schmid, Hocine Tighouart (2012). Estimating Glomerular Filtration Rate from serum Creatinine and Cystatin C. New England Journal of Medicine, 367(1), 20-29.
Mussap M., Dalla Vestra, Paola Fioretto et al. (2002). Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients. Kidney International, 61(4), 1453-1461.
Nabil A. El-Kafrawy, Ahmed A. Shohaib, Samar M. Kamal El-Deen, et al. (2014). Evaluation of serum cystatin C as an indicator of early renal function decline in type 2 diabetes. Menoufia Medical Journal, 27(1), 60-65.
Jeon Y.L., Kim M.H., Lee W.I., Kang S.Y. (2013). Cystatin C as an early marker of diabetic nephropathy in patients with type 2 diabetes. Clinical Laboratory, 59(11-12), 1221-1229.
Stevens G. (2002). Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. American Journal of Kidney Diseases, 40(2), 221-226.
| Published | 27-04-2021 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | No. 68 (2021) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2021.68.14 | |
| Keywords | Bệnh thận do đái tháo đường, Cystatin C, Mức lọc cầu thận Diabetic nephropathy, Cystatin C, GFR |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Journal of Clinical Medicine Hue Central Hospital